Plasma neuropeptide Y levels rise in patients undergoing exercise tests for the investigation of chest pain

M. J. Morris, J. M. Elliott, M. D. Cain, V. Kapoor, M. J. West, J. P. Chalmers

    Research output: Contribution to journalArticle

    35 Citations (Scopus)

    Abstract

    1. Neuropeptide Y (NPY) is colocalised with noradrenaline in post‐ganglionic sympathetic neurons. In order to examine the possibility that activation of the sympathetic nervous system might cause release of NPY into the plasma NPY levels were measured in 16 patients undergoing exercise tests for investigation of chest pain. 2. Plasma NPY concentrations rose in 14 out of the 16 patients, and the mean level of plasma NPY increased from 335 (s.e.m. = 37) to 455 (s.e.m. = 41) pg/ml. 3. Plasma noradrenaline and adrenaline levels increased four‐ and two‐fold respectively. 4. The increase in NPY correlated with the increase in noradrenaline, suggesting that NPY may be released with noradrenaline when sympathetic noradrenergic nerves are activated.

    Original languageEnglish
    Pages (from-to)437-440
    Number of pages4
    JournalClinical and Experimental Pharmacology and Physiology
    Volume13
    Issue number5
    DOIs
    Publication statusPublished - May 1986

    Keywords

    • co‐release
    • exercise
    • neuropeptide Y
    • noradrenaline
    • sympathetic activation.

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