Plasma neuropeptide Y levels rise in patients undergoing exercise tests for the investigation of chest pain

M. J. Morris; J. M. Elliott; M. D. Cain; V. Kapoor; M. J. West; J. P. Chalmers

doi:10.1111/j.1440-1681.1986.tb00923.x

Plasma neuropeptide Y levels rise in patients undergoing exercise tests for the investigation of chest pain

M. J. Morris, J. M. Elliott, M. D. Cain, V. Kapoor, M. J. West, J. P. Chalmers

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Abstract

1. Neuropeptide Y (NPY) is colocalised with noradrenaline in post‐ganglionic sympathetic neurons. In order to examine the possibility that activation of the sympathetic nervous system might cause release of NPY into the plasma NPY levels were measured in 16 patients undergoing exercise tests for investigation of chest pain. 2. Plasma NPY concentrations rose in 14 out of the 16 patients, and the mean level of plasma NPY increased from 335 (s.e.m. = 37) to 455 (s.e.m. = 41) pg/ml. 3. Plasma noradrenaline and adrenaline levels increased four‐ and two‐fold respectively. 4. The increase in NPY correlated with the increase in noradrenaline, suggesting that NPY may be released with noradrenaline when sympathetic noradrenergic nerves are activated.

Original language	English
Pages (from-to)	437-440
Number of pages	4
Journal	Clinical and Experimental Pharmacology and Physiology
Volume	13
Issue number	5
DOIs	https://doi.org/10.1111/j.1440-1681.1986.tb00923.x
Publication status	Published - May 1986

Keywords

co‐release
exercise
neuropeptide Y
noradrenaline
sympathetic activation.

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abstract = "1. Neuropeptide Y (NPY) is colocalised with noradrenaline in post‐ganglionic sympathetic neurons. In order to examine the possibility that activation of the sympathetic nervous system might cause release of NPY into the plasma NPY levels were measured in 16 patients undergoing exercise tests for investigation of chest pain. 2. Plasma NPY concentrations rose in 14 out of the 16 patients, and the mean level of plasma NPY increased from 335 (s.e.m. = 37) to 455 (s.e.m. = 41) pg/ml. 3. Plasma noradrenaline and adrenaline levels increased four‐ and two‐fold respectively. 4. The increase in NPY correlated with the increase in noradrenaline, suggesting that NPY may be released with noradrenaline when sympathetic noradrenergic nerves are activated.",

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AU - Morris, M. J.

AU - Elliott, J. M.

AU - Cain, M. D.

AU - Kapoor, V.

AU - West, M. J.

AU - Chalmers, J. P.

PY - 1986/5

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N2 - 1. Neuropeptide Y (NPY) is colocalised with noradrenaline in post‐ganglionic sympathetic neurons. In order to examine the possibility that activation of the sympathetic nervous system might cause release of NPY into the plasma NPY levels were measured in 16 patients undergoing exercise tests for investigation of chest pain. 2. Plasma NPY concentrations rose in 14 out of the 16 patients, and the mean level of plasma NPY increased from 335 (s.e.m. = 37) to 455 (s.e.m. = 41) pg/ml. 3. Plasma noradrenaline and adrenaline levels increased four‐ and two‐fold respectively. 4. The increase in NPY correlated with the increase in noradrenaline, suggesting that NPY may be released with noradrenaline when sympathetic noradrenergic nerves are activated.

AB - 1. Neuropeptide Y (NPY) is colocalised with noradrenaline in post‐ganglionic sympathetic neurons. In order to examine the possibility that activation of the sympathetic nervous system might cause release of NPY into the plasma NPY levels were measured in 16 patients undergoing exercise tests for investigation of chest pain. 2. Plasma NPY concentrations rose in 14 out of the 16 patients, and the mean level of plasma NPY increased from 335 (s.e.m. = 37) to 455 (s.e.m. = 41) pg/ml. 3. Plasma noradrenaline and adrenaline levels increased four‐ and two‐fold respectively. 4. The increase in NPY correlated with the increase in noradrenaline, suggesting that NPY may be released with noradrenaline when sympathetic noradrenergic nerves are activated.

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KW - exercise

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Plasma neuropeptide Y levels rise in patients undergoing exercise tests for the investigation of chest pain

Abstract

Keywords

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