Plasma polymer barrier layers to control the release kinetics from dissolvable microneedle patches

Laura E. González García, Melanie MacGregor, Alex Cavallaro, Kaloian Koynov, Krasimir Vasilev

Research output: Contribution to journalArticlepeer-review

Abstract

Dissolving microneedles are a noninvasive transdermal drug delivery platform that offers painless needle-free patient treatment. Current strategies to control the kinetics of drug release from the polymeric microneedle patches consist of adjusting the bulk polymer formulations and/or encapsulating the cargo in controlled delivery vehicles. Instead, in this study, the drug release rates were altered by modifying the surface properties of the microneedles using plasma polymer coatings with tailored properties. The main advantage of this one-step, solvent-free, and scalable method is that it can be applied to any type of microneedles regardless of their drug cargo or bulk material. Octadiene plasma polymer films were found to suppress the burst release effect of otherwise rapidly dissolving microneedles and to reduce the dissolution rate by a factor of four compared to uncoated control patches. The approach presented in this study offers an alternative, highly tunable, and customizable strategy for controlling drug release rate from microneedle patches.

Original languageEnglish
Article numbere2200099
Number of pages8
JournalPlasma Processes and Polymers
Volume19
Issue number12
Early online date28 Jul 2022
DOIs
Publication statusPublished - Dec 2022

Keywords

  • drug release
  • microneedle
  • octadiene
  • plasma polymers

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