TY - JOUR
T1 - Plasma polymer barrier layers to control the release kinetics from dissolvable microneedle patches
AU - González García, Laura E.
AU - MacGregor, Melanie
AU - Cavallaro, Alex
AU - Koynov, Kaloian
AU - Vasilev, Krasimir
PY - 2022/12
Y1 - 2022/12
N2 - Dissolving microneedles are a noninvasive transdermal drug delivery platform that offers painless needle-free patient treatment. Current strategies to control the kinetics of drug release from the polymeric microneedle patches consist of adjusting the bulk polymer formulations and/or encapsulating the cargo in controlled delivery vehicles. Instead, in this study, the drug release rates were altered by modifying the surface properties of the microneedles using plasma polymer coatings with tailored properties. The main advantage of this one-step, solvent-free, and scalable method is that it can be applied to any type of microneedles regardless of their drug cargo or bulk material. Octadiene plasma polymer films were found to suppress the burst release effect of otherwise rapidly dissolving microneedles and to reduce the dissolution rate by a factor of four compared to uncoated control patches. The approach presented in this study offers an alternative, highly tunable, and customizable strategy for controlling drug release rate from microneedle patches.
AB - Dissolving microneedles are a noninvasive transdermal drug delivery platform that offers painless needle-free patient treatment. Current strategies to control the kinetics of drug release from the polymeric microneedle patches consist of adjusting the bulk polymer formulations and/or encapsulating the cargo in controlled delivery vehicles. Instead, in this study, the drug release rates were altered by modifying the surface properties of the microneedles using plasma polymer coatings with tailored properties. The main advantage of this one-step, solvent-free, and scalable method is that it can be applied to any type of microneedles regardless of their drug cargo or bulk material. Octadiene plasma polymer films were found to suppress the burst release effect of otherwise rapidly dissolving microneedles and to reduce the dissolution rate by a factor of four compared to uncoated control patches. The approach presented in this study offers an alternative, highly tunable, and customizable strategy for controlling drug release rate from microneedle patches.
KW - drug release
KW - microneedle
KW - octadiene
KW - plasma polymers
UR - http://www.scopus.com/inward/record.url?scp=85135056487&partnerID=8YFLogxK
UR - http://purl.org/au-research/grants/ARC/DP180101254
UR - http://purl.org/au-research/grants/ARC/FT200100301
UR - http://purl.org/au-research/grants/NHMRC/1194466
U2 - 10.1002/ppap.202200099
DO - 10.1002/ppap.202200099
M3 - Article
AN - SCOPUS:85135056487
VL - 19
JO - Plasma Processes and Polymers
JF - Plasma Processes and Polymers
SN - 1612-8850
IS - 12
M1 - e2200099
ER -