TY - JOUR
T1 - Plasma polymers from oregano secondary metabolites
T2 - Antibacterial and biocompatible plant-based polymers
AU - Romo-Rico, Jesus
AU - Murali Krishna, Smriti
AU - Golledge, Jonathan
AU - Hayles, Andrew
AU - Vasilev, Krasimir
AU - Jacob, Mohan V.
PY - 2022/7
Y1 - 2022/7
N2 - Bacterial infection of chronic wounds is a major healthcare problem that affects the quality of life of millions of patients worldwide and leads to a substantial healthcare cost burden. This project focused on the manufacture of a potential wound healing agent. Plasma polymers from oregano secondary metabolites (PP-OSMs) were fabricated by radiofrequency plasma-enhanced chemical vapor deposition (RF-PECVD) in continuous and pulse plasma modes at room temperature. The surface, biocompatibility, and antibacterial properties of the PP-OSMs were investigated. Polymers fabricated by RF-PECVD retained the functional groups of OSMs, promoted human dermal fibroblast adhesion, inhibited Staphylococcus aureus attachment, and eliminated Pseudomonas aeruginosa. The PP-OSM coatings are potential candidates for use in medical applications where cell biocompatibility and antibacterial properties are required.
AB - Bacterial infection of chronic wounds is a major healthcare problem that affects the quality of life of millions of patients worldwide and leads to a substantial healthcare cost burden. This project focused on the manufacture of a potential wound healing agent. Plasma polymers from oregano secondary metabolites (PP-OSMs) were fabricated by radiofrequency plasma-enhanced chemical vapor deposition (RF-PECVD) in continuous and pulse plasma modes at room temperature. The surface, biocompatibility, and antibacterial properties of the PP-OSMs were investigated. Polymers fabricated by RF-PECVD retained the functional groups of OSMs, promoted human dermal fibroblast adhesion, inhibited Staphylococcus aureus attachment, and eliminated Pseudomonas aeruginosa. The PP-OSM coatings are potential candidates for use in medical applications where cell biocompatibility and antibacterial properties are required.
KW - antibacterial
KW - biocompatible
KW - oregano
KW - plant secondary metabolites
KW - plasma polymers
UR - http://www.scopus.com/inward/record.url?scp=85127254363&partnerID=8YFLogxK
UR - http://purl.org/au-research/grants/NHMRC/1194466
U2 - 10.1002/ppap.202100220
DO - 10.1002/ppap.202100220
M3 - Article
AN - SCOPUS:85127254363
SN - 1612-8850
VL - 19
JO - Plasma Processes and Polymers
JF - Plasma Processes and Polymers
IS - 7
M1 - 2100220
ER -
