Plasma Profiling Reveals a Blood-Based Metabolic Fingerprint of Obstructive Sleep Apnea

RATIONALE: Obstructive sleep apnea (OSA) is a chronic, heterogeneous and multicomponent disorder with associated cardiovascular and metabolic alterations. Despite being the most common sleep-disordered breathing, it remains a significantly undiagnosed condition. The study of metabolism at the molecular level has emerged as a tool with great potential not only in the identification of novel biomarkers, but also can contribute to the understanding of disease pathogenesis. We examined the complete plasma metabolome and lipidome of patients with suspected OSA, with the aim of identifying potential diagnosis biomarkers and providing insights into the pathophysiological mechanisms underlying the disease. Additionally, we evaluated the impact of continuous positive airway pressure (CPAP) treatment on the circulating metabolomic and lipidomic profile.