Plasma protein thiols: an early marker of oxidative stress in asthma and chronic obstructive pulmonary disease

Angelo Zinellu, Alessandro Fois, Salvatore Sotgia, Elisabetta Zinellu, Fabiana Bifulco, Gianfranco Pintus, Arduino Mangoni, Ciriaco Carru, Pietro Pirina

    Research output: Contribution to journalArticlepeer-review

    25 Citations (Scopus)

    Abstract

    Chronic obstructive pulmonary disease (COPD) and asthma are both characterized by heterogeneous chronic airway inflammation and obstruction as well as oxidative stress (OS). However, it is unknown whether OS occurs in early disease and how to best assess its presence. Plasma OS markers (TBARS, PSH, taurine, GSH, ergothioneine and paraoxonase 1 activity) and lung function tests were measured in patients with mild stable asthma (n = 24) and mild stable COPD (n = 29) and in age- and sex-matched controls. Forced expiratory volume in 1 s (FEV1) was associated with age both in patients and control groups. By contrast, FEV1 was positively correlated with PSH only in COPD (ρ = 0·49, P = 0·007). In multiple logistic regression analysis, lower PSH was the only OS marker independently associated with increased odds of both asthma (OR = 0·32, 95% CI 0·13-0·78, P = 0·01) and COPD (OR = 0·50, 95% CI 0·26-0·95, P = 0·03). These findings suggest that proteins -SH are a sensitive OS marker in early COPD and asthma.

    Original languageEnglish
    Pages (from-to)181-188
    Number of pages8
    JournalEUROPEAN JOURNAL OF CLINICAL INVESTIGATION
    Volume46
    Issue number2
    DOIs
    Publication statusPublished - 1 Feb 2016

    Keywords

    • Asthma
    • COPD
    • Early marker
    • Oxidative stress
    • Proteins -SH

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