Polyacrylate Dendrimer Nanoparticles: A Self‐Adjuvanting Vaccine Delivery System

Mariusz Skwarczynski; Mehfuz Zaman; Carl N. Urbani; I. Chun Lin; Zhongfan Jia; Michael R. Batzloff; Michael F. Good; Michael J. Monteiro; Istvan Toth

doi:10.1002/anie.201002221

Polyacrylate Dendrimer Nanoparticles: A Self‐Adjuvanting Vaccine Delivery System

Mariusz Skwarczynski, Mehfuz Zaman, Carl N. Urbani, I. Chun Lin, Zhongfan Jia, Michael R. Batzloff, Michael F. Good, Michael J. Monteiro, Istvan Toth

Research output: Contribution to journal › Article › peer-review

116 Citations (Scopus)

Abstract

(Figure Presented) Special delivery: An effective group A streptococci vaccine is formed from a delivery device consisting of well-defined dendritic structures with nanoscale dimensions (see picture). The structures are designed to display multiple copies of the minimal B-cell epitopes, which were in the optimal conformation on the surface of the nanoparticles. The nanoparticles can be administered without the aid of an adjuvant.

Original language	English
Pages (from-to)	5742-5745
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	49
Issue number	33
DOIs	https://doi.org/10.1002/anie.201002221
Publication status	Published - 2 Aug 2010
Externally published	Yes

Keywords

Amphiphiles
Dendrimers
Drug delivery
Nanoparticles
Self-assembly

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title = "Polyacrylate Dendrimer Nanoparticles: A Self‐Adjuvanting Vaccine Delivery System",

abstract = "(Figure Presented) Special delivery: An effective group A streptococci vaccine is formed from a delivery device consisting of well-defined dendritic structures with nanoscale dimensions (see picture). The structures are designed to display multiple copies of the minimal B-cell epitopes, which were in the optimal conformation on the surface of the nanoparticles. The nanoparticles can be administered without the aid of an adjuvant.",

keywords = "Amphiphiles, Dendrimers, Drug delivery, Nanoparticles, Self-assembly",

author = "Mariusz Skwarczynski and Mehfuz Zaman and Urbani, {Carl N.} and Lin, {I. Chun} and Zhongfan Jia and Batzloff, {Michael R.} and Good, {Michael F.} and Monteiro, {Michael J.} and Istvan Toth",

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Polyacrylate Dendrimer Nanoparticles : A Self‐Adjuvanting Vaccine Delivery System. / Skwarczynski, Mariusz; Zaman, Mehfuz; Urbani, Carl N.; Lin, I. Chun; Jia, Zhongfan; Batzloff, Michael R.; Good, Michael F.; Monteiro, Michael J.; Toth, Istvan.

In: Angewandte Chemie - International Edition, Vol. 49, No. 33, 02.08.2010, p. 5742-5745.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Polyacrylate Dendrimer Nanoparticles

T2 - A Self‐Adjuvanting Vaccine Delivery System

AU - Skwarczynski, Mariusz

AU - Zaman, Mehfuz

AU - Urbani, Carl N.

AU - Lin, I. Chun

AU - Jia, Zhongfan

AU - Batzloff, Michael R.

AU - Good, Michael F.

AU - Monteiro, Michael J.

AU - Toth, Istvan

PY - 2010/8/2

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N2 - (Figure Presented) Special delivery: An effective group A streptococci vaccine is formed from a delivery device consisting of well-defined dendritic structures with nanoscale dimensions (see picture). The structures are designed to display multiple copies of the minimal B-cell epitopes, which were in the optimal conformation on the surface of the nanoparticles. The nanoparticles can be administered without the aid of an adjuvant.

AB - (Figure Presented) Special delivery: An effective group A streptococci vaccine is formed from a delivery device consisting of well-defined dendritic structures with nanoscale dimensions (see picture). The structures are designed to display multiple copies of the minimal B-cell epitopes, which were in the optimal conformation on the surface of the nanoparticles. The nanoparticles can be administered without the aid of an adjuvant.

KW - Amphiphiles

KW - Dendrimers

KW - Drug delivery

KW - Nanoparticles

KW - Self-assembly

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Polyacrylate Dendrimer Nanoparticles: A Self‐Adjuvanting Vaccine Delivery System

Abstract

Keywords

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