Abstract
(Figure Presented) Special delivery: An effective group A streptococci vaccine is formed from a delivery device consisting of well-defined dendritic structures with nanoscale dimensions (see picture). The structures are designed to display multiple copies of the minimal B-cell epitopes, which were in the optimal conformation on the surface of the nanoparticles. The nanoparticles can be administered without the aid of an adjuvant.
Original language | English |
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Pages (from-to) | 5742-5745 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 49 |
Issue number | 33 |
DOIs | |
Publication status | Published - 2 Aug 2010 |
Externally published | Yes |
Keywords
- Amphiphiles
- Dendrimers
- Drug delivery
- Nanoparticles
- Self-assembly