Polyacrylate Dendrimer Nanoparticles: A Self‐Adjuvanting Vaccine Delivery System

Mariusz Skwarczynski, Mehfuz Zaman, Carl N. Urbani, I. Chun Lin, Zhongfan Jia, Michael R. Batzloff, Michael F. Good, Michael J. Monteiro, Istvan Toth

Research output: Contribution to journalArticlepeer-review

116 Citations (Scopus)

Abstract

(Figure Presented) Special delivery: An effective group A streptococci vaccine is formed from a delivery device consisting of well-defined dendritic structures with nanoscale dimensions (see picture). The structures are designed to display multiple copies of the minimal B-cell epitopes, which were in the optimal conformation on the surface of the nanoparticles. The nanoparticles can be administered without the aid of an adjuvant.

Original languageEnglish
Pages (from-to)5742-5745
Number of pages4
JournalAngewandte Chemie - International Edition
Volume49
Issue number33
DOIs
Publication statusPublished - 2 Aug 2010
Externally publishedYes

Keywords

  • Amphiphiles
  • Dendrimers
  • Drug delivery
  • Nanoparticles
  • Self-assembly

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