Polyelectrolyte-coated gold nanoparticles: The effect of salt and polyelectrolyte concentration on colloidal stability

Melanie Fuller, Ingo Köper

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    Gold nanoparticles are widely used in biomedical applications. Their ease of surface modification, biocompatibility and the presence of surface plasmons makes them ideal tools for a variety of investigations. Polyelectrolyte-coated gold nanoparticles are employed in areas such as imaging, drug delivery and gene therapy; however, it is not well understood how different factors such as the polyelectrolyte and salt concentration affect the coating on the nanoparticles and hence their performance. Here, these parameters were systematically varied and their effect on the stability of the colloidal nanoparticle suspension was monitored. An increase in the polyelectrolyte concentration from 0 to 30 mg/mL led to a red shift of the surface plasmon peak and an increase in the zeta potential. Concentrations between 5 mg/mL and 30 mg/mL resulted in the most stable systems, with 1 mg/mL being the most unstable. Stable nanoparticle suspensions were formed in salt concentrations below 50 mM, while higher concentrations caused colloidal instability and irreversible aggregation.

    Original languageEnglish
    Article number1336
    Number of pages9
    JournalPolymers
    Volume10
    Issue number12
    DOIs
    Publication statusPublished - 3 Dec 2018

    Keywords

    • Biomedical
    • Gold
    • Gold nanoparticles
    • Polyelectrolyte
    • Stability

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