Polygenic Risk Scores for Atherosclerotic Cardiovascular Disease in the Asia-Pacific Region

Hayato Tada; Khung Keong Yeo; Jian-Jun Li; Kathryn Tan; Junya Ako; Rungroj Krittayaphong; Ru San Tan; Philip E. Aylward; Carolyn S.P. Lam; Sang Hong Baek; Jamshed Dalal; Alan Fong; Yi-Heng Li; Richard C. O'Brien; Si Ya Natalie Koh; Daniel J. Scherer; Vernon Kang; Adam J. Nelson; Julie Butters; Stephen J. Nicholls

doi:10.1016/j.jacasi.2021.08.008

Polygenic Risk Scores for Atherosclerotic Cardiovascular Disease in the Asia-Pacific Region

Hayato Tada, Khung Keong Yeo, Jian-Jun Li, Kathryn Tan, Junya Ako, Rungroj Krittayaphong, Ru San Tan, Philip E. Aylward, Carolyn S.P. Lam, Sang Hong Baek, Jamshed Dalal, Alan Fong, Yi-Heng Li, Richard C. O'Brien, Si Ya Natalie Koh, Daniel J. Scherer, Vernon Kang, Adam J. Nelson, Julie Butters, Stephen J. Nicholls

College of Medicine and Public Health

Research output: Contribution to journal › Review article › peer-review

8 Citations (Scopus)

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Abstract

Approximately one-half of the phenotypic susceptibility to atherosclerotic cardiovascular disease (ASCVD) has a genetic basis. Although individual allelic variants generally impart a small effect on risk for ASCVD, an emerging body of data has shown that the aggregation and weighting of many of these genetic variations into “scores” can further discriminate an individual's risk beyond traditional risk factors alone. Consistent with the theory of population genetics, such polygenic risk scores (PRS) appear to be ethnicity specific because their elements comprise single-nucleotide variants that are always ethnicity specific. The currently available PRS are derived predominantly from European ancestry and thus predictably perform less well among non-European participants, a fact that has implications for their use in the Asia-Pacific region. This paper describes the current state of knowledge of PRS, the available data that support their use in this region, and highlights the needs moving forward to safely and effectively implement them in clinical care in the Asia-Pacific region.

Original language	English
Pages (from-to)	294-302
Number of pages	9
Journal	JACC: Asia
Volume	1
Issue number	3
DOIs	https://doi.org/10.1016/j.jacasi.2021.08.008
Publication status	Published - Dec 2021

Keywords

Asia-Pacific
cardiovascular disease
genetics
polygenic risk score

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jacasi.2021.08.008Licence: CC BY-NC-ND

Published versionFinal published version, 965 KBLicence: CC BY-NC-ND

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Tada, H., Yeo, K. K., Li, J.-J., Tan, K., Ako, J., Krittayaphong, R., San Tan, R., Aylward, P. E., Lam, C. S. P., Baek, S. H., Dalal, J., Fong, A., Li, Y.-H., O'Brien, R. C., Natalie Koh, S. Y., Scherer, D. J., Kang, V., Nelson, A. J., Butters, J., & Nicholls, S. J. (2021). Polygenic Risk Scores for Atherosclerotic Cardiovascular Disease in the Asia-Pacific Region. JACC: Asia, 1(3), 294-302. https://doi.org/10.1016/j.jacasi.2021.08.008

@article{979aee5dd9d04d91aff4443ec809f7b6,

title = "Polygenic Risk Scores for Atherosclerotic Cardiovascular Disease in the Asia-Pacific Region",

abstract = "Approximately one-half of the phenotypic susceptibility to atherosclerotic cardiovascular disease (ASCVD) has a genetic basis. Although individual allelic variants generally impart a small effect on risk for ASCVD, an emerging body of data has shown that the aggregation and weighting of many of these genetic variations into “scores” can further discriminate an individual's risk beyond traditional risk factors alone. Consistent with the theory of population genetics, such polygenic risk scores (PRS) appear to be ethnicity specific because their elements comprise single-nucleotide variants that are always ethnicity specific. The currently available PRS are derived predominantly from European ancestry and thus predictably perform less well among non-European participants, a fact that has implications for their use in the Asia-Pacific region. This paper describes the current state of knowledge of PRS, the available data that support their use in this region, and highlights the needs moving forward to safely and effectively implement them in clinical care in the Asia-Pacific region.",

keywords = "Asia-Pacific, cardiovascular disease, genetics, polygenic risk score",

author = "Hayato Tada and Yeo, {Khung Keong} and Jian-Jun Li and Kathryn Tan and Junya Ako and Rungroj Krittayaphong and {San Tan}, Ru and Aylward, {Philip E.} and Lam, {Carolyn S.P.} and Baek, {Sang Hong} and Jamshed Dalal and Alan Fong and Yi-Heng Li and O'Brien, {Richard C.} and {Natalie Koh}, {Si Ya} and Scherer, {Daniel J.} and Vernon Kang and Nelson, {Adam J.} and Julie Butters and Nicholls, {Stephen J.}",

year = "2021",

month = dec,

doi = "10.1016/j.jacasi.2021.08.008",

language = "English",

volume = "1",

pages = "294--302",

journal = "JACC: Asia",

issn = "2772-3747",

publisher = "Elsevier Inc.",

number = "3",

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Tada, H, Yeo, KK, Li, J-J, Tan, K, Ako, J, Krittayaphong, R, San Tan, R, Aylward, PE, Lam, CSP, Baek, SH, Dalal, J, Fong, A, Li, Y-H, O'Brien, RC, Natalie Koh, SY, Scherer, DJ, Kang, V, Nelson, AJ, Butters, J & Nicholls, SJ 2021, 'Polygenic Risk Scores for Atherosclerotic Cardiovascular Disease in the Asia-Pacific Region', JACC: Asia, vol. 1, no. 3, pp. 294-302. https://doi.org/10.1016/j.jacasi.2021.08.008

TY - JOUR

T1 - Polygenic Risk Scores for Atherosclerotic Cardiovascular Disease in the Asia-Pacific Region

AU - Tada, Hayato

AU - Yeo, Khung Keong

AU - Li, Jian-Jun

AU - Tan, Kathryn

AU - Ako, Junya

AU - Krittayaphong, Rungroj

AU - San Tan, Ru

AU - Aylward, Philip E.

AU - Lam, Carolyn S.P.

AU - Baek, Sang Hong

AU - Dalal, Jamshed

AU - Fong, Alan

AU - Li, Yi-Heng

AU - O'Brien, Richard C.

AU - Natalie Koh, Si Ya

AU - Scherer, Daniel J.

AU - Kang, Vernon

AU - Nelson, Adam J.

AU - Butters, Julie

AU - Nicholls, Stephen J.

PY - 2021/12

Y1 - 2021/12

N2 - Approximately one-half of the phenotypic susceptibility to atherosclerotic cardiovascular disease (ASCVD) has a genetic basis. Although individual allelic variants generally impart a small effect on risk for ASCVD, an emerging body of data has shown that the aggregation and weighting of many of these genetic variations into “scores” can further discriminate an individual's risk beyond traditional risk factors alone. Consistent with the theory of population genetics, such polygenic risk scores (PRS) appear to be ethnicity specific because their elements comprise single-nucleotide variants that are always ethnicity specific. The currently available PRS are derived predominantly from European ancestry and thus predictably perform less well among non-European participants, a fact that has implications for their use in the Asia-Pacific region. This paper describes the current state of knowledge of PRS, the available data that support their use in this region, and highlights the needs moving forward to safely and effectively implement them in clinical care in the Asia-Pacific region.

AB - Approximately one-half of the phenotypic susceptibility to atherosclerotic cardiovascular disease (ASCVD) has a genetic basis. Although individual allelic variants generally impart a small effect on risk for ASCVD, an emerging body of data has shown that the aggregation and weighting of many of these genetic variations into “scores” can further discriminate an individual's risk beyond traditional risk factors alone. Consistent with the theory of population genetics, such polygenic risk scores (PRS) appear to be ethnicity specific because their elements comprise single-nucleotide variants that are always ethnicity specific. The currently available PRS are derived predominantly from European ancestry and thus predictably perform less well among non-European participants, a fact that has implications for their use in the Asia-Pacific region. This paper describes the current state of knowledge of PRS, the available data that support their use in this region, and highlights the needs moving forward to safely and effectively implement them in clinical care in the Asia-Pacific region.

KW - Asia-Pacific

KW - cardiovascular disease

KW - genetics

KW - polygenic risk score

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U2 - 10.1016/j.jacasi.2021.08.008

DO - 10.1016/j.jacasi.2021.08.008

M3 - Review article

AN - SCOPUS:85132177662

SN - 2772-3747

VL - 1

SP - 294

EP - 302

JO - JACC: Asia

JF - JACC: Asia

IS - 3

ER -

Polygenic Risk Scores for Atherosclerotic Cardiovascular Disease in the Asia-Pacific Region

Abstract

Keywords

UN SDGs

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