Polymerization-Amplified Optical DNA Detection on Porous Silicon Templates

Dirk Holthausen; Roshan Vasani; Steven McInnes; Amanda Ellis; Nicolas Voelcker

doi:10.1021/mz300064k

Polymerization-Amplified Optical DNA Detection on Porous Silicon Templates

Dirk Holthausen, Roshan Vasani, Steven McInnes, Amanda Ellis, Nicolas Voelcker

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

A porous silicon-based optical DNA sensor is described herein, which enables rapid DNA detection. The DNA sensor relies on the specificity of the DNA base pairing in conjunction with an interferometric optical signal amplification step based on polymer formation within the porous silicon layer to detect the DNA targets in a highly selective fashion. We demonstrate that it is possible to discriminate between DNA strands exhibiting even a single nucleotide mismatch using this sensor.

Original language	English
Pages (from-to)	919-921
Number of pages	3
Journal	ACS Macro Letters
Volume	1
Issue number	7
DOIs	https://doi.org/10.1021/mz300064k
Publication status	Published - 17 Jul 2012

Access to Document

10.1021/mz300064k

Cite this

@article{bab5b24363ec460aa8ab6af63c4635c1,

title = "Polymerization-Amplified Optical DNA Detection on Porous Silicon Templates",

abstract = "A porous silicon-based optical DNA sensor is described herein, which enables rapid DNA detection. The DNA sensor relies on the specificity of the DNA base pairing in conjunction with an interferometric optical signal amplification step based on polymer formation within the porous silicon layer to detect the DNA targets in a highly selective fashion. We demonstrate that it is possible to discriminate between DNA strands exhibiting even a single nucleotide mismatch using this sensor.",

author = "Dirk Holthausen and Roshan Vasani and Steven McInnes and Amanda Ellis and Nicolas Voelcker",

year = "2012",

month = jul,

day = "17",

doi = "10.1021/mz300064k",

language = "English",

volume = "1",

pages = "919--921",

journal = "ACS Macro Letters",

issn = "2161-1653",

publisher = "Americal Chemical Society",

number = "7",

}

TY - JOUR

T1 - Polymerization-Amplified Optical DNA Detection on Porous Silicon Templates

AU - Holthausen, Dirk

AU - Vasani, Roshan

AU - McInnes, Steven

AU - Ellis, Amanda

AU - Voelcker, Nicolas

PY - 2012/7/17

Y1 - 2012/7/17

N2 - A porous silicon-based optical DNA sensor is described herein, which enables rapid DNA detection. The DNA sensor relies on the specificity of the DNA base pairing in conjunction with an interferometric optical signal amplification step based on polymer formation within the porous silicon layer to detect the DNA targets in a highly selective fashion. We demonstrate that it is possible to discriminate between DNA strands exhibiting even a single nucleotide mismatch using this sensor.

AB - A porous silicon-based optical DNA sensor is described herein, which enables rapid DNA detection. The DNA sensor relies on the specificity of the DNA base pairing in conjunction with an interferometric optical signal amplification step based on polymer formation within the porous silicon layer to detect the DNA targets in a highly selective fashion. We demonstrate that it is possible to discriminate between DNA strands exhibiting even a single nucleotide mismatch using this sensor.

UR - http://www.scopus.com/inward/record.url?scp=84874233257&partnerID=8YFLogxK

U2 - 10.1021/mz300064k

DO - 10.1021/mz300064k

M3 - Article

SN - 2161-1653

VL - 1

SP - 919

EP - 921

JO - ACS Macro Letters

JF - ACS Macro Letters

IS - 7

ER -

Polymerization-Amplified Optical DNA Detection on Porous Silicon Templates

Abstract

Access to Document

Other files and links

Fingerprint

Cite this