Polymerization-Amplified Optical DNA Detection on Porous Silicon Templates

Dirk Holthausen, Roshan Vasani, Steven McInnes, Amanda Ellis, Nicolas Voelcker

    Research output: Contribution to journalArticlepeer-review

    17 Citations (Scopus)

    Abstract

    A porous silicon-based optical DNA sensor is described herein, which enables rapid DNA detection. The DNA sensor relies on the specificity of the DNA base pairing in conjunction with an interferometric optical signal amplification step based on polymer formation within the porous silicon layer to detect the DNA targets in a highly selective fashion. We demonstrate that it is possible to discriminate between DNA strands exhibiting even a single nucleotide mismatch using this sensor.

    Original languageEnglish
    Pages (from-to)919-921
    Number of pages3
    JournalACS Macro Letters
    Volume1
    Issue number7
    DOIs
    Publication statusPublished - 2012

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