Poor Response to Direct-Acting Antiviral Therapy in HCV-Infected Elderly Population: A Real-Life Cohort Study Based on GeneXpert® Technology

Braira Wahid; Muhammad Waqar; Komal Saleem; Faiza Shafi; Zobaria Rehman; Iqra Hanif; Hafiza Maleeha Ahmad; Muhammad Wasim; Sajjad; Khansa Wahid; Muhammad Idrees

doi:10.2217/fvl-2017-0158

Poor Response to Direct-Acting Antiviral Therapy in HCV-Infected Elderly Population: A Real-Life Cohort Study Based on GeneXpert® Technology

Braira Wahid, Muhammad Waqar, Komal Saleem, Faiza Shafi, Zobaria Rehman, Iqra Hanif, Hafiza Maleeha Ahmad, Muhammad Wasim, Sajjad, Khansa Wahid, Muhammad Idrees

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Aim: This study aimed to determine the efficacy of direct-acting antiviral drugs in different ethnicities and elderly population of Pakistan.

Methods: We used GeneXpert^® technology to quantify HCV RNA and evaluated treatment response in different cohorts that included HCV patients classified on the basis of their age-group and ethnicity.

Results: The findings of our study suggest that 76% of nonresponder patients were older than 55 years of age which shows that age is the predictor of treatment outcome of direct-acting antiviral drugs. In addition to this, no differences were observed in overall efficacy by ethnicity.

Conclusion: Treatment-regimen sofosbuvir+ribavirin has a limited effect on older patients; therefore, practitioners and healthcare professionals need to reconsider treatment options for elderly populations.

Original language	English
Pages (from-to)	467-474
Number of pages	8
Journal	Future Virology
Volume	13
Issue number	7
DOIs	https://doi.org/10.2217/fvl-2017-0158
Publication status	Published - 2018
Externally published	Yes

Keywords

DAA drug
elderly population
GCMBDR
HCV
Pakistan
treatment response

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title = "Poor Response to Direct-Acting Antiviral Therapy in HCV-Infected Elderly Population: A Real-Life Cohort Study Based on GeneXpert{\textregistered} Technology",

abstract = "Aim: This study aimed to determine the efficacy of direct-acting antiviral drugs in different ethnicities and elderly population of Pakistan. Methods: We used GeneXpert{\textregistered} technology to quantify HCV RNA and evaluated treatment response in different cohorts that included HCV patients classified on the basis of their age-group and ethnicity. Results: The findings of our study suggest that 76% of nonresponder patients were older than 55 years of age which shows that age is the predictor of treatment outcome of direct-acting antiviral drugs. In addition to this, no differences were observed in overall efficacy by ethnicity. Conclusion: Treatment-regimen sofosbuvir+ribavirin has a limited effect on older patients; therefore, practitioners and healthcare professionals need to reconsider treatment options for elderly populations.",

keywords = "DAA drug, elderly population, GCMBDR, HCV, Pakistan, treatment response",

author = "Braira Wahid and Muhammad Waqar and Komal Saleem and Faiza Shafi and Zobaria Rehman and Iqra Hanif and Ahmad, {Hafiza Maleeha} and Muhammad Wasim and Sajjad and Khansa Wahid and Muhammad Idrees",

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doi = "10.2217/fvl-2017-0158",

language = "English",

volume = "13",

pages = "467--474",

journal = "Future Virology",

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TY - JOUR

T1 - Poor Response to Direct-Acting Antiviral Therapy in HCV-Infected Elderly Population

T2 - A Real-Life Cohort Study Based on GeneXpert® Technology

AU - Wahid, Braira

AU - Waqar, Muhammad

AU - Saleem, Komal

AU - Shafi, Faiza

AU - Rehman, Zobaria

AU - Hanif, Iqra

AU - Ahmad, Hafiza Maleeha

AU - Wasim, Muhammad

AU - Sajjad,

AU - Wahid, Khansa

AU - Idrees, Muhammad

PY - 2018

Y1 - 2018

N2 - Aim: This study aimed to determine the efficacy of direct-acting antiviral drugs in different ethnicities and elderly population of Pakistan. Methods: We used GeneXpert® technology to quantify HCV RNA and evaluated treatment response in different cohorts that included HCV patients classified on the basis of their age-group and ethnicity. Results: The findings of our study suggest that 76% of nonresponder patients were older than 55 years of age which shows that age is the predictor of treatment outcome of direct-acting antiviral drugs. In addition to this, no differences were observed in overall efficacy by ethnicity. Conclusion: Treatment-regimen sofosbuvir+ribavirin has a limited effect on older patients; therefore, practitioners and healthcare professionals need to reconsider treatment options for elderly populations.

AB - Aim: This study aimed to determine the efficacy of direct-acting antiviral drugs in different ethnicities and elderly population of Pakistan. Methods: We used GeneXpert® technology to quantify HCV RNA and evaluated treatment response in different cohorts that included HCV patients classified on the basis of their age-group and ethnicity. Results: The findings of our study suggest that 76% of nonresponder patients were older than 55 years of age which shows that age is the predictor of treatment outcome of direct-acting antiviral drugs. In addition to this, no differences were observed in overall efficacy by ethnicity. Conclusion: Treatment-regimen sofosbuvir+ribavirin has a limited effect on older patients; therefore, practitioners and healthcare professionals need to reconsider treatment options for elderly populations.

KW - DAA drug

KW - elderly population

KW - GCMBDR

KW - HCV

KW - Pakistan

KW - treatment response

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DO - 10.2217/fvl-2017-0158

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SN - 1746-0794

VL - 13

SP - 467

EP - 474

JO - Future Virology

JF - Future Virology

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ER -

Poor Response to Direct-Acting Antiviral Therapy in HCV-Infected Elderly Population: A Real-Life Cohort Study Based on GeneXpert® Technology

Abstract

Keywords

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