Porous Silicon Nanodiscs for Targeted Drug Delivery

Hashim Alhmoud, Bahman Delalat, Roey Elnathan, Anna Cifuentes-Rius, Mary-Louise Rogers, Arnaud Chaix, Jean-Olivier Durand, Nicholas Voelcker

    Research output: Contribution to journalArticlepeer-review

    65 Citations (Scopus)

    Abstract

    There is a strong demand for techniques that allow the fabrication of biocompatible porous nanoparticles for drug delivery applications. In this work, a new method to fabricate size- and shape-controlled porous silicon (pSi) nanodiscs is described. The process relies on a combination of colloidal lithography and metal-assisted chemical etching. Height and diameter of the pSi nanodiscs can be easily adjusted. The nanodiscs are degradable in physiological milieu and are nontoxic to mammalian cells. In order to highlight the potential of the pSi nanodiscs in drug delivery, an in vitro investigation that involved loading of nanodiscs with the anticancer agent camptothecin and functionalization of the nanodisc periphery with an antibody that targets receptors on the surface of neuroblastoma cells is carried out. The thus-prepared nanocarriers are found to selectively attach to and kill cancer cells.

    Original languageEnglish
    Pages (from-to)1137-1145
    Number of pages9
    JournalAdvanced Functional Materials
    Volume25
    Issue number7
    DOIs
    Publication statusPublished - 18 Feb 2015

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