TY - JOUR
T1 - Post-acute sequelae of SARS-CoV-2 cardiovascular symptoms are associated with trace-level cytokines that affect cardiomyocyte function
AU - Sinclair, Jane E.
AU - Vedelago, Courtney
AU - Ryan, Feargal J.
AU - Carney, Meagan
AU - Redd, Meredith A.
AU - Lynn, Miriam A.
AU - Grubor-Bauk, Branka
AU - Cao, Yuanzhao
AU - Henders, Anjali K.
AU - Chew, Keng Yih
AU - Gilroy, Deborah
AU - Greaves, Kim
AU - Labzin, Larisa
AU - Ziser, Laura
AU - Ronacher, Katharina
AU - Wallace, Leanne M.
AU - Zhang, Yiwen
AU - Macauslane, Kyle
AU - Ellis, Daniel J.
AU - Rao, Sudha
AU - Burr, Lucy
AU - Bain, Amanda
AU - Karawita, Anjana
AU - Schulz, Benjamin L.
AU - Li, Junrong
AU - Lynn, David J.
AU - Palpant, Nathan
AU - Wuethrich, Alain
AU - Trau, Matt
AU - Short, Kirsty R.
PY - 2024/12
Y1 - 2024/12
N2 - An estimated 65 million people globally suffer from post-acute sequelae of COVID-19 (PASC), with many experiencing cardiovascular symptoms (PASC-CVS) like chest pain and heart palpitations. This study examines the role of chronic inflammation in PASC-CVS, particularly in individuals with symptoms persisting over a year after infection. Blood samples from three groups—recovered individuals, those with prolonged PASC-CVS and SARS-CoV-2-negative individuals—revealed that those with PASC-CVS had a blood signature linked to inflammation. Trace-level pro-inflammatory cytokines were detected in the plasma from donors with PASC-CVS 18 months post infection using nanotechnology. Importantly, these trace-level cytokines affected the function of primary human cardiomyocytes. Plasma proteomics also demonstrated higher levels of complement and coagulation proteins in the plasma from patients with PASC-CVS. This study highlights chronic inflammation’s role in the symptoms of PASC-CVS.
AB - An estimated 65 million people globally suffer from post-acute sequelae of COVID-19 (PASC), with many experiencing cardiovascular symptoms (PASC-CVS) like chest pain and heart palpitations. This study examines the role of chronic inflammation in PASC-CVS, particularly in individuals with symptoms persisting over a year after infection. Blood samples from three groups—recovered individuals, those with prolonged PASC-CVS and SARS-CoV-2-negative individuals—revealed that those with PASC-CVS had a blood signature linked to inflammation. Trace-level pro-inflammatory cytokines were detected in the plasma from donors with PASC-CVS 18 months post infection using nanotechnology. Importantly, these trace-level cytokines affected the function of primary human cardiomyocytes. Plasma proteomics also demonstrated higher levels of complement and coagulation proteins in the plasma from patients with PASC-CVS. This study highlights chronic inflammation’s role in the symptoms of PASC-CVS.
KW - Post-acute sequelae of COVID-19 (PASC)
KW - SARS-CoV-2
KW - cardiovascular symptoms
KW - trace-level cytokines
KW - cardiomyocyte function
KW - viral infection
KW - PASC-CVS
KW - plasma proteome
KW - plasma
UR - http://www.scopus.com/inward/record.url?scp=85208078627&partnerID=8YFLogxK
UR - http://purl.org/au-research/grants/ARC/DP210103151
UR - http://purl.org/au-research/grants/ARC/FL220100059
UR - http://purl.org/au-research/grants/ARC/LE220100068
UR - http://purl.org/au-research/grants/NHMRC/1175047
UR - http://purl.org/au-research/grants/NHMRC/1185907
UR - http://purl.org/au-research/grants/NHMRC/2010757
UR - http://purl.org/au-research/grants/NHMRC/1173669
UR - http://purl.org/au-research/grants/NHMRC/2034488
UR - http://purl.org/au-research/grants/NHMRC/1113400
U2 - 10.1038/s41564-024-01838-z
DO - 10.1038/s41564-024-01838-z
M3 - Article
AN - SCOPUS:85208078627
SN - 2058-5276
VL - 9
SP - 3135
EP - 3147
JO - Nature Microbiology
JF - Nature Microbiology
IS - 12
ER -