Post-operative anorectal manometry in children with Hirschsprung disease: A systematic review

Hannah M.E. Evans-Barns, Justina B. Swannjo, Misel Trajanovska, Mark Safe, John M. Hutson, Phil G. Dinning, Sebastian K. King

Research output: Contribution to journalReview articlepeer-review

Abstract

Background: Hirschsprung disease is commonly encountered by pediatric surgeons. Despite advances in the surgical management, these children may experience symptoms of bowel dysfunction throughout adulthood. Anorectal manometry may be used to assess post-operative anorectal structure and function. This review aimed to consolidate and evaluate the literature pertaining to post-operative findings of anorectal manometry in children with Hirschsprung disease. Purpose: (1) Synthesize the available data regarding anorectal motility patterns in children following repair of Hirschsprung disease. (2) Evaluate the reported anorectal manometry protocols. Data Sources: We performed a systematic review of four databases: Embase, MEDLINE, the Cochrane Library, and PubMed. Study Selection: This systematic review was performed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Studies reporting results of post-operative anorectal manometry in children with Hirschsprung disease were evaluated for inclusion. Results: Twenty-three studies satisfied inclusion criteria, with a combined cohort of 939 patients. Post-operative anorectal manometry results were reported for 682 children. The majority of included studies were assessed as “poor quality.” Disparate manometry protocols, heterogeneous cohorts, and lack of standardized outcome assessments introduced a risk of outcome reporting bias, limited the comparability of results, and impeded clinical translation of findings. Conclusions: This systematic review demonstrated the lack of high-quality evidence underlying the current understanding of post-operative anorectal motility in children with HD. There was little consistency in reported manometry outcomes between studies. In future work, emphasis must be placed on the application of standardized manometry protocols, cohort reporting, and patient outcome assessments.

Original languageEnglish
Article numbere14311
Number of pages24
JournalNeurogastroenterology and Motility
Volume34
Issue number8
Early online date29 Dec 2021
DOIs
Publication statusPublished - Aug 2022

Keywords

  • gastrointestinal motility
  • high-resolution manometry
  • Hirschsprung disease
  • manometry
  • anorectum

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