Post Proline Cleaving Peptidases Having DP IV Like Enzyme Activity: Post-proline peptidases

Catherine A. Abbott, Denise Yu, Geoffrey W. McCaughan, Mark D. Gorrell

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

DP IV has been studied extensively in disease and in the immune system by the use of enzyme assays which detect hydrolysis of Gly-Pro or Ala-Pro substrate. In addition many studies have used inhibitors of DP IV enzyme activity. The characterisation of a novel DP IV like protein, DPP4R, and of other proteases which have a substrate specificity similar to DP IV or that bind DP IV inhibitors suggests that these studies require further evaluation.

Original languageEnglish
Pages (from-to)103-109
Number of pages7
JournalAdvances in Experimental Medicine and Biology
Volume477
DOIs
Publication statusPublished - 1 Jan 2000
Externally publishedYes

Keywords

  • Dipeptidyl peptidase IV
  • Prolyl oligopeptidase
  • Serine protease

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