Post Proline Cleaving Peptidases Having DP IV Like Enzyme Activity: Post-proline peptidases

Catherine A. Abbott, Denise Yu, Geoffrey W. McCaughan, Mark D. Gorrell

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

DP IV has been studied extensively in disease and in the immune system by the use of enzyme assays which detect hydrolysis of Gly-Pro or Ala-Pro substrate. In addition many studies have used inhibitors of DP IV enzyme activity. The characterisation of a novel DP IV like protein, DPP4R, and of other proteases which have a substrate specificity similar to DP IV or that bind DP IV inhibitors suggests that these studies require further evaluation.

Original languageEnglish
Pages (from-to)103-109
Number of pages7
JournalAdvances in Experimental Medicine and Biology
Volume477
DOIs
Publication statusPublished - 1 Jan 2000
Externally publishedYes

Keywords

  • Dipeptidyl peptidase IV
  • Prolyl oligopeptidase
  • Serine protease

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