Post Proline Cleaving Peptidases Having DP IV Like Enzyme Activity: Post-proline peptidases

Catherine A. Abbott; Denise Yu; Geoffrey W. McCaughan; Mark D. Gorrell

doi:10.1007/0-306-46826-3_10

Post Proline Cleaving Peptidases Having DP IV Like Enzyme Activity: Post-proline peptidases

Catherine A. Abbott, Denise Yu, Geoffrey W. McCaughan, Mark D. Gorrell

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

DP IV has been studied extensively in disease and in the immune system by the use of enzyme assays which detect hydrolysis of Gly-Pro or Ala-Pro substrate. In addition many studies have used inhibitors of DP IV enzyme activity. The characterisation of a novel DP IV like protein, DPP4R, and of other proteases which have a substrate specificity similar to DP IV or that bind DP IV inhibitors suggests that these studies require further evaluation.

Original language	English
Pages (from-to)	103-109
Number of pages	7
Journal	Advances in Experimental Medicine and Biology
Volume	477
DOIs	https://doi.org/10.1007/0-306-46826-3_10
Publication status	Published - 1 Jan 2000
Externally published	Yes

Keywords

Dipeptidyl peptidase IV
Prolyl oligopeptidase
Serine protease

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author = "Abbott, {Catherine A.} and Denise Yu and McCaughan, {Geoffrey W.} and Gorrell, {Mark D.}",

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AU - Yu, Denise

AU - McCaughan, Geoffrey W.

AU - Gorrell, Mark D.

PY - 2000/1/1

Y1 - 2000/1/1

N2 - DP IV has been studied extensively in disease and in the immune system by the use of enzyme assays which detect hydrolysis of Gly-Pro or Ala-Pro substrate. In addition many studies have used inhibitors of DP IV enzyme activity. The characterisation of a novel DP IV like protein, DPP4R, and of other proteases which have a substrate specificity similar to DP IV or that bind DP IV inhibitors suggests that these studies require further evaluation.

AB - DP IV has been studied extensively in disease and in the immune system by the use of enzyme assays which detect hydrolysis of Gly-Pro or Ala-Pro substrate. In addition many studies have used inhibitors of DP IV enzyme activity. The characterisation of a novel DP IV like protein, DPP4R, and of other proteases which have a substrate specificity similar to DP IV or that bind DP IV inhibitors suggests that these studies require further evaluation.

KW - Dipeptidyl peptidase IV

KW - Prolyl oligopeptidase

KW - Serine protease

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JF - Advances in Experimental Medicine and Biology

ER -

Post Proline Cleaving Peptidases Having DP IV Like Enzyme Activity: Post-proline peptidases

Abstract

Keywords

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