Post-transcriptional Gene Regulation by MicroRNA-194 Promotes Neuroendocrine Transdifferentiation in Prostate Cancer

Rayzel C. Fernandes; John Toubia; Scott Townley; Adrienne R. Hanson; B. Kate Dredge; Katherine A. Pillman; Andrew G. Bert; Jean M. Winter; Richard Iggo; Rajdeep Das; Daisuke Obinata; MURAL investigators; Shahneen Sandhu; Gail P. Risbridger; Renea A. Taylor; Mitchell G. Lawrence; Lisa M. Butler; Amina Zoubeidi; Philip A. Gregory; Wayne D. Tilley; Theresa E. Hickey; Gregory J. Goodall; Luke A. Selth

doi:10.1016/j.celrep.2020.108585

Post-transcriptional Gene Regulation by MicroRNA-194 Promotes Neuroendocrine Transdifferentiation in Prostate Cancer

Rayzel C. Fernandes, John Toubia, Scott Townley, Adrienne R. Hanson, B. Kate Dredge, Katherine A. Pillman, Andrew G. Bert, Jean M. Winter, Richard Iggo, Rajdeep Das, Daisuke Obinata, MURAL investigators, Shahneen Sandhu, Gail P. Risbridger, Renea A. Taylor, Mitchell G. Lawrence, Lisa M. Butler, Amina Zoubeidi, Philip A. Gregory, Wayne D. TilleyTheresa E. Hickey, Gregory J. Goodall, Luke A. Selth

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Abstract

Neuroendocrine prostate cancer is an aggressive disease subtype associated with poor patient outcome. Fernandes et al. demonstrate that a microRNA, miR-194, promotes the emergence of neuroendocrine features in prostate cancer cells by targeting genes that regulate epithelial-neuroendocrine plasticity. Inhibiting miR-194 suppresses the growth of neuroendocrine prostate cancer models.

Original language	English
Article number	108585
Number of pages	24
Journal	Cell Reports
Volume	34
Issue number	1
DOIs	https://doi.org/10.1016/j.celrep.2020.108585
Publication status	Published - 5 Jan 2021
Externally published	Yes

Keywords

FOXA1
lineage plasticity
microRNA
miR-194
neuroendocrine prostate cancer
post-transcriptional gene regulation
prostate cancer
transdifferentiation

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Published versionFinal published version, 5.43 MBLicence: CC BY-NC-ND

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Fernandes, R. C., Toubia, J., Townley, S., Hanson, A. R., Dredge, B. K., Pillman, K. A., Bert, A. G., Winter, J. M., Iggo, R., Das, R., Obinata, D., MURAL investigators, Sandhu, S., Risbridger, G. P., Taylor, R. A., Lawrence, M. G., Butler, L. M., Zoubeidi, A., Gregory, P. A., ... Selth, L. A. (2021). Post-transcriptional Gene Regulation by MicroRNA-194 Promotes Neuroendocrine Transdifferentiation in Prostate Cancer. Cell Reports, 34(1), [108585]. https://doi.org/10.1016/j.celrep.2020.108585

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title = "Post-transcriptional Gene Regulation by MicroRNA-194 Promotes Neuroendocrine Transdifferentiation in Prostate Cancer",

abstract = "Neuroendocrine prostate cancer is an aggressive disease subtype associated with poor patient outcome. Fernandes et al. demonstrate that a microRNA, miR-194, promotes the emergence of neuroendocrine features in prostate cancer cells by targeting genes that regulate epithelial-neuroendocrine plasticity. Inhibiting miR-194 suppresses the growth of neuroendocrine prostate cancer models.",

keywords = "FOXA1, lineage plasticity, microRNA, miR-194, neuroendocrine prostate cancer, post-transcriptional gene regulation, prostate cancer, transdifferentiation",

author = "Fernandes, {Rayzel C.} and John Toubia and Scott Townley and Hanson, {Adrienne R.} and Dredge, {B. Kate} and Pillman, {Katherine A.} and Bert, {Andrew G.} and Winter, {Jean M.} and Richard Iggo and Rajdeep Das and Daisuke Obinata and {MURAL investigators} and Shahneen Sandhu and Risbridger, {Gail P.} and Taylor, {Renea A.} and Lawrence, {Mitchell G.} and Butler, {Lisa M.} and Amina Zoubeidi and Gregory, {Philip A.} and Tilley, {Wayne D.} and Hickey, {Theresa E.} and Goodall, {Gregory J.} and Selth, {Luke A.}",

year = "2021",

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doi = "10.1016/j.celrep.2020.108585",

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Fernandes, RC, Toubia, J, Townley, S, Hanson, AR, Dredge, BK, Pillman, KA, Bert, AG, Winter, JM, Iggo, R, Das, R, Obinata, D, MURAL investigators, Sandhu, S, Risbridger, GP, Taylor, RA, Lawrence, MG, Butler, LM, Zoubeidi, A, Gregory, PA, Tilley, WD, Hickey, TE, Goodall, GJ & Selth, LA 2021, 'Post-transcriptional Gene Regulation by MicroRNA-194 Promotes Neuroendocrine Transdifferentiation in Prostate Cancer', Cell Reports, vol. 34, no. 1, 108585. https://doi.org/10.1016/j.celrep.2020.108585

TY - JOUR

T1 - Post-transcriptional Gene Regulation by MicroRNA-194 Promotes Neuroendocrine Transdifferentiation in Prostate Cancer

AU - Fernandes, Rayzel C.

AU - Toubia, John

AU - Townley, Scott

AU - Hanson, Adrienne R.

AU - Dredge, B. Kate

AU - Pillman, Katherine A.

AU - Bert, Andrew G.

AU - Winter, Jean M.

AU - Iggo, Richard

AU - Das, Rajdeep

AU - Obinata, Daisuke

AU - MURAL investigators

AU - Sandhu, Shahneen

AU - Risbridger, Gail P.

AU - Taylor, Renea A.

AU - Lawrence, Mitchell G.

AU - Butler, Lisa M.

AU - Zoubeidi, Amina

AU - Gregory, Philip A.

AU - Tilley, Wayne D.

AU - Hickey, Theresa E.

AU - Goodall, Gregory J.

AU - Selth, Luke A.

PY - 2021/1/5

Y1 - 2021/1/5

N2 - Neuroendocrine prostate cancer is an aggressive disease subtype associated with poor patient outcome. Fernandes et al. demonstrate that a microRNA, miR-194, promotes the emergence of neuroendocrine features in prostate cancer cells by targeting genes that regulate epithelial-neuroendocrine plasticity. Inhibiting miR-194 suppresses the growth of neuroendocrine prostate cancer models.

AB - Neuroendocrine prostate cancer is an aggressive disease subtype associated with poor patient outcome. Fernandes et al. demonstrate that a microRNA, miR-194, promotes the emergence of neuroendocrine features in prostate cancer cells by targeting genes that regulate epithelial-neuroendocrine plasticity. Inhibiting miR-194 suppresses the growth of neuroendocrine prostate cancer models.

KW - FOXA1

KW - lineage plasticity

KW - microRNA

KW - miR-194

KW - neuroendocrine prostate cancer

KW - post-transcriptional gene regulation

KW - prostate cancer

KW - transdifferentiation

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JO - Cell Reports

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ER -

Post-transcriptional Gene Regulation by MicroRNA-194 Promotes Neuroendocrine Transdifferentiation in Prostate Cancer

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