Post-transcriptional Gene Regulation by MicroRNA-194 Promotes Neuroendocrine Transdifferentiation in Prostate Cancer

Rayzel C. Fernandes, John Toubia, Scott Townley, Adrienne R. Hanson, B. Kate Dredge, Katherine A. Pillman, Andrew G. Bert, Jean M. Winter, Richard Iggo, Rajdeep Das, Daisuke Obinata, MURAL investigators, Shahneen Sandhu, Gail P. Risbridger, Renea A. Taylor, Mitchell G. Lawrence, Lisa M. Butler, Amina Zoubeidi, Philip A. Gregory, Wayne D. TilleyTheresa E. Hickey, Gregory J. Goodall, Luke A. Selth

Research output: Contribution to journalArticlepeer-review

Abstract

Neuroendocrine prostate cancer is an aggressive disease subtype associated with poor patient outcome. Fernandes et al. demonstrate that a microRNA, miR-194, promotes the emergence of neuroendocrine features in prostate cancer cells by targeting genes that regulate epithelial-neuroendocrine plasticity. Inhibiting miR-194 suppresses the growth of neuroendocrine prostate cancer models.

Original languageEnglish
Article number108585
Number of pages24
JournalCell Reports
Volume34
Issue number1
DOIs
Publication statusPublished - 5 Jan 2021
Externally publishedYes

Keywords

  • FOXA1
  • lineage plasticity
  • microRNA
  • miR-194
  • neuroendocrine prostate cancer
  • post-transcriptional gene regulation
  • prostate cancer
  • transdifferentiation

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