Abstract
Neuroendocrine prostate cancer is an aggressive disease subtype associated with poor patient outcome. Fernandes et al. demonstrate that a microRNA, miR-194, promotes the emergence of neuroendocrine features in prostate cancer cells by targeting genes that regulate epithelial-neuroendocrine plasticity. Inhibiting miR-194 suppresses the growth of neuroendocrine prostate cancer models.
Original language | English |
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Article number | 108585 |
Number of pages | 24 |
Journal | Cell Reports |
Volume | 34 |
Issue number | 1 |
DOIs | |
Publication status | Published - 5 Jan 2021 |
Externally published | Yes |
Keywords
- FOXA1
- lineage plasticity
- microRNA
- miR-194
- neuroendocrine prostate cancer
- post-transcriptional gene regulation
- prostate cancer
- transdifferentiation