Postinfectious brainstem encephalitis associated with SARS-CoV-2

Anthony Khoo; Benjamin McLoughlin; Sanjay Cheema; Rimona S. Weil; Christian Lambert; Hadi Manji; Michael S. Zandi; Jasper M. Morrow

doi:10.1136/jnnp-2020-323816

Postinfectious brainstem encephalitis associated with SARS-CoV-2

Anthony Khoo, Benjamin McLoughlin, Sanjay Cheema, Rimona S. Weil, Christian Lambert, Hadi Manji, Michael S. Zandi, Jasper M. Morrow

Research output: Contribution to journal › Letter › peer-review

67 Citations (Scopus)

Abstract

Immune-mediated neurological sequelae following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are becoming increasingly evident, and can affect both the peripheral and central nervous system. We report a postinfectious brainstem syndrome in a patient with COVID-19 who presented with generalised myoclonus, ocular flutter with convergence spasm and acquired hyperekplexia. Clinical improvement was seen following corticosteroids, highlighting this as a possible treatment in patients where a post-COVID-19 autoimmune encephalitis is suspected.

Original language	English
Pages (from-to)	1013-1014
Number of pages	2
Journal	Journal of Neurology, Neurosurgery and Psychiatry
Volume	91
Issue number	9
Early online date	7 Jul 2020
DOIs	https://doi.org/10.1136/jnnp-2020-323816
Publication status	Published - 1 Sept 2020
Externally published	Yes

Keywords

encephalitis
COVID-19
SARS-CoV-2
Case report

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abstract = "Immune-mediated neurological sequelae following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are becoming increasingly evident, and can affect both the peripheral and central nervous system. We report a postinfectious brainstem syndrome in a patient with COVID-19 who presented with generalised myoclonus, ocular flutter with convergence spasm and acquired hyperekplexia. Clinical improvement was seen following corticosteroids, highlighting this as a possible treatment in patients where a post-COVID-19 autoimmune encephalitis is suspected.",

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AU - Khoo, Anthony

AU - McLoughlin, Benjamin

AU - Cheema, Sanjay

AU - Weil, Rimona S.

AU - Lambert, Christian

AU - Manji, Hadi

AU - Zandi, Michael S.

AU - Morrow, Jasper M.

PY - 2020/9/1

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N2 - Immune-mediated neurological sequelae following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are becoming increasingly evident, and can affect both the peripheral and central nervous system. We report a postinfectious brainstem syndrome in a patient with COVID-19 who presented with generalised myoclonus, ocular flutter with convergence spasm and acquired hyperekplexia. Clinical improvement was seen following corticosteroids, highlighting this as a possible treatment in patients where a post-COVID-19 autoimmune encephalitis is suspected.

AB - Immune-mediated neurological sequelae following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are becoming increasingly evident, and can affect both the peripheral and central nervous system. We report a postinfectious brainstem syndrome in a patient with COVID-19 who presented with generalised myoclonus, ocular flutter with convergence spasm and acquired hyperekplexia. Clinical improvement was seen following corticosteroids, highlighting this as a possible treatment in patients where a post-COVID-19 autoimmune encephalitis is suspected.

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KW - COVID-19

KW - SARS-CoV-2

KW - Case report

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JO - Journal of Neurology, Neurosurgery & Psychiatry

JF - Journal of Neurology, Neurosurgery & Psychiatry

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ER -

Postinfectious brainstem encephalitis associated with SARS-CoV-2

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