Postinfectious brainstem encephalitis associated with SARS-CoV-2

Anthony Khoo; Benjamin McLoughlin; Sanjay Cheema; Rimona S. Weil; Christian Lambert; Hadi Manji; Michael S. Zandi; Jasper M. Morrow

doi:10.1136/jnnp-2020-323816

Postinfectious brainstem encephalitis associated with SARS-CoV-2

Anthony Khoo, Benjamin McLoughlin, Sanjay Cheema, Rimona S. Weil, Christian Lambert, Hadi Manji, Michael S. Zandi, Jasper M. Morrow

Research output: Contribution to journal › Letter › peer-review

80 Citations (Scopus)

Abstract

Immune-mediated neurological sequelae following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are becoming increasingly evident, and can affect both the peripheral and central nervous system. We report a postinfectious brainstem syndrome in a patient with COVID-19 who presented with generalised myoclonus, ocular flutter with convergence spasm and acquired hyperekplexia. Clinical improvement was seen following corticosteroids, highlighting this as a possible treatment in patients where a post-COVID-19 autoimmune encephalitis is suspected.

Original language	English
Pages (from-to)	1013-1014
Number of pages	2
Journal	Journal of Neurology, Neurosurgery and Psychiatry
Volume	91
Issue number	9
Early online date	7 Jul 2020
DOIs	https://doi.org/10.1136/jnnp-2020-323816
Publication status	Published - 1 Sept 2020
Externally published	Yes

Keywords

encephalitis
COVID-19
SARS-CoV-2
Case report

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1136/jnnp-2020-323816Licence: In Copyright

Cite this

@article{41d26b86e3b2445b8b512c13f11a9e2e,

title = "Postinfectious brainstem encephalitis associated with SARS-CoV-2",

abstract = "Immune-mediated neurological sequelae following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are becoming increasingly evident, and can affect both the peripheral and central nervous system. We report a postinfectious brainstem syndrome in a patient with COVID-19 who presented with generalised myoclonus, ocular flutter with convergence spasm and acquired hyperekplexia. Clinical improvement was seen following corticosteroids, highlighting this as a possible treatment in patients where a post-COVID-19 autoimmune encephalitis is suspected.",

keywords = "encephalitis, COVID-19, SARS-CoV-2, Case report",

author = "Anthony Khoo and Benjamin McLoughlin and Sanjay Cheema and Weil, {Rimona S.} and Christian Lambert and Hadi Manji and Zandi, {Michael S.} and Morrow, {Jasper M.}",

year = "2020",

month = sep,

day = "1",

doi = "10.1136/jnnp-2020-323816",

language = "English",

volume = "91",

pages = "1013--1014",

journal = "Journal of Neurology, Neurosurgery and Psychiatry",

issn = "0022-3050",

publisher = "BMJ Publishing Group Ltd",

number = "9",

}

TY - JOUR

T1 - Postinfectious brainstem encephalitis associated with SARS-CoV-2

AU - Khoo, Anthony

AU - McLoughlin, Benjamin

AU - Cheema, Sanjay

AU - Weil, Rimona S.

AU - Lambert, Christian

AU - Manji, Hadi

AU - Zandi, Michael S.

AU - Morrow, Jasper M.

PY - 2020/9/1

Y1 - 2020/9/1

N2 - Immune-mediated neurological sequelae following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are becoming increasingly evident, and can affect both the peripheral and central nervous system. We report a postinfectious brainstem syndrome in a patient with COVID-19 who presented with generalised myoclonus, ocular flutter with convergence spasm and acquired hyperekplexia. Clinical improvement was seen following corticosteroids, highlighting this as a possible treatment in patients where a post-COVID-19 autoimmune encephalitis is suspected.

AB - Immune-mediated neurological sequelae following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are becoming increasingly evident, and can affect both the peripheral and central nervous system. We report a postinfectious brainstem syndrome in a patient with COVID-19 who presented with generalised myoclonus, ocular flutter with convergence spasm and acquired hyperekplexia. Clinical improvement was seen following corticosteroids, highlighting this as a possible treatment in patients where a post-COVID-19 autoimmune encephalitis is suspected.

KW - encephalitis

KW - COVID-19

KW - SARS-CoV-2

KW - Case report

UR - http://www.scopus.com/inward/record.url?scp=85089711733&partnerID=8YFLogxK

U2 - 10.1136/jnnp-2020-323816

DO - 10.1136/jnnp-2020-323816

M3 - Letter

C2 - 32636212

AN - SCOPUS:85089711733

SN - 0022-3050

VL - 91

SP - 1013

EP - 1014

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

IS - 9

ER -

Postinfectious brainstem encephalitis associated with SARS-CoV-2

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this