Postoperative cognitive dysfunction after total joint arthroplasty in the elderly: A meta-analysis

Julia Erin Scott, Jane Mathias, Anthony Christopher Kneebone

    Research output: Contribution to journalReview articlepeer-review

    32 Citations (Scopus)


    This meta-analysis consolidated the research on postoperative cognitive dysfunction (POCD) following total joint arthroplasty (TJA). Data from 17 studies that assessed cognition pre- and post-surgery in TJA patients alone (15 studies) or matched TJA and control groups (2 studies) were analysed. Results were grouped by cognitive domain (memory, attention, language, speed, general cognition) and follow-up interval (pre-discharge, 3-6 months post-surgery). The TJA data revealed small declines in reaction time and general cognition pre-discharge, but no evidence of decline 3–6 months post-surgery. Very limited TJA and Control data indicated no group differences in the changes to performance over time; however, the TJA group was cognitively compromised pre- and post-surgery compared to Controls. Further appropriately controlled research is required to clarify whether POCD commonly occurs after TJA.
    Original languageEnglish
    Pages (from-to)261-267.e1
    Number of pages8
    JournalJournal of Arthroplasty
    Issue number2
    Publication statusPublished - Feb 2014


    • total joint arthroplasty
    • post-operative cognitive dysfunction
    • elderly
    • meta-analysis
    • outcomes


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