Potential causes of the preoperative increase in the rectosigmoid cyclic motor pattern: A high-resolution manometry study

Cameron I. Wells, Sameer Bhat, Nira Paskaranandavadivel, Anthony Y. Lin, Ryash Vather, Chris Varghese, James A. Penfold, David Rowbotham, Phil G. Dinning, Ian P. Bissett, Greg O’Grady

Research output: Contribution to journalArticlepeer-review

21 Downloads (Pure)

Abstract

Background: Cyclic motor patterns (CMPs) are the most common motor pattern in the distal colon. This study used high-resolution (HR) colonic manometry to quantify trends in distal colonic motor activity before elective colonic surgery, determine the effect of a preoperative carbohydrate load, and compare this with a meal response in healthy controls. Methods: Fiber-optic HR colonic manometry (36 sensors, 1 cm intervals) was used to investigate distal colonic motor activity in 10 adult patients prior to elective colonic surgery, 6 of whom consumed a preoperative carbohydrate drink (200 kCal). Data were compared with nine healthy volunteers who underwent HR colonic manometry recordings while fasted and following a 700 kCal meal. The primary outcome was the percentage of recording occupied by CMPs, defined as propagating contractions at 2–4 cycles per minute (cpm). Secondary outcomes included amplitude, speed, and distance of propagating motor patterns. Results: The occurrence of CMPs progressively increased in time periods closer to surgery (p = 0.001). Consumption of a preoperative drink resulted in significantly increased CMP occurrence (p = 0.04) and propagating distance (p = 0.04). There were no changes in amplitude or speed of propagating motor patterns during the preoperative period. The increase in activity following a preoperative drink was of similar magnitude to the colonic meal response observed in healthy controls, despite the lesser caloric nutrient load. Conclusion: Distal colonic CMP increased in occurrence prior to surgery, amplified by ingestion of preoperative carbohydrate drinks. We hypothesize that anxiety, which is also known to rise with proximity to surgery, could play a contributing role.

Original languageEnglish
Article numbere15091
Number of pages10
JournalPhysiological Reports
Volume9
Issue number22
DOIs
Publication statusPublished - Nov 2021

Keywords

  • colonic manometry
  • motility
  • oral carbohydrate
  • preoperative

Fingerprint

Dive into the research topics of 'Potential causes of the preoperative increase in the rectosigmoid cyclic motor pattern: A high-resolution manometry study'. Together they form a unique fingerprint.

Cite this