Precision medicine technology hype or reality? The example of computer-guided dosing

Thomas M. Polasek, Sepehr Shakib, Amin Rostami-Hodjegan

Research output: Contribution to journalComment/debate

4 Citations (Scopus)
26 Downloads (Pure)


Novel technologies labelled as ‘precision medicine’ are targeting all aspects of clinical care. Whilst some technological advances are undeniably exciting, many doctors at the frontline of healthcare view precision medicine as being out of reach for their patients. Computer-guided dosing is a precision medicine technology that predicts drug concentrations and drug responses based on individual patient characteristics. In this opinion piece, the example of computer-guided dosing is used to illustrate eight features of a precision medicine technology less likely to be hyperbole and more likely to improve patient care. Positive features in this regard include: (1) fitting the definition of ‘precision medicine’; (2) addressing a major clinical problem that negatively impacts patient care; (3) a track record of high-quality medical science published via peer-reviewed literature; (4) well-defined clinical cases for application; (5) quality evidence of benefits measured by various clinical, patient and health economic endpoints; (6) strong economic drivers; (7) user friendliness, including easy integration into clinical workflow, and (8) recognition of importance by patients and their endorsement for broader clinical use. Barriers raised by critics of the approach are given to balance the view. The value of computer-guided dosing will be decided ultimately by the extent to which it can improve cost-effective patient care.

Original languageEnglish
Article number1709
Number of pages10
Publication statusPublished - 1 Oct 2019
Externally publishedYes

Bibliographical note

Copyright: © 2019 Polasek TM et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


  • Computer-guided dosing
  • Individualized drug therapy
  • Model-informed precision dosing
  • Personalized medicine
  • Precision dosing
  • Precision medicine


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