Preganglionic parasympathetic neurons projecting to the sphenopalatine ganglion contain nitric oxide synthase in the rabbit

Bao Song Zhu; Ian L. Gibbins; William W. Blessing

doi:10.1016/S0006-8993(97)00844-5

Preganglionic parasympathetic neurons projecting to the sphenopalatine ganglion contain nitric oxide synthase in the rabbit

Bao Song Zhu, Ian L. Gibbins, William W. Blessing

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

We have investigated the possible presence of nitric oxide synthase (NOS) and choline acetyltransferase (ChAT) in brainstem preganglionic parasympathetic neurons projecting to the sphenopalatine ganglion in rabbits, using combined retrograde axonal tracing and immunohistochemistry. Retrogradely labeled neurons were observed in the ipsilateral rostral medulla and caudal pons, in a region laterodorsal to the facial motor nucleus. Double-labeling experiments demonstrated that 75 ± 5% of retrogradely labeled neurons contained NOS immunoreactivity, while all of retrogradely labeled neurons contained ChAT immunoreactivity. These observations suggest that nitric oxide could influence cholinergic transmission from preganglionic endings in the sphenopalatine ganglion.

Original language	English
Pages (from-to)	168-172
Number of pages	5
Journal	Brain Research
Volume	769
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(97)00844-5
Publication status	Published - 19 Sep 1997

Keywords

Brainstem
Choline acetyltransferase
Nitric oxide synthase
Parasympathetic pathway
Retrograde tracing
Sphenopalatine ganglion

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abstract = "We have investigated the possible presence of nitric oxide synthase (NOS) and choline acetyltransferase (ChAT) in brainstem preganglionic parasympathetic neurons projecting to the sphenopalatine ganglion in rabbits, using combined retrograde axonal tracing and immunohistochemistry. Retrogradely labeled neurons were observed in the ipsilateral rostral medulla and caudal pons, in a region laterodorsal to the facial motor nucleus. Double-labeling experiments demonstrated that 75 ± 5% of retrogradely labeled neurons contained NOS immunoreactivity, while all of retrogradely labeled neurons contained ChAT immunoreactivity. These observations suggest that nitric oxide could influence cholinergic transmission from preganglionic endings in the sphenopalatine ganglion.",

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