Pregnancy Complications Are Associated with Premature Coronary Artery Disease: Linking Three Cohorts

Adeel Khoja, Prabha H. Andraweera, Rosanna Tavella, Tiffany K. Gill, Gustaaf A. Dekker, Claire T. Roberts, Suzanne Edwards, Margaret A. Arstall

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background: There is increasing evidence that women who experience placenta-mediated pregnancy complications and gestational diabetes mellitus (GDM) are at higher risk for the development of coronary artery disease (CAD) later in life. We hypothesized that there is an association between placenta-mediated pregnancy complications, GDM, and risk of premature CAD (PCAD).

Methods: This research project involved a data linkage approach merging three databases of South Australian cohorts by using a retrospective, age-matched case?control study design. Cases (n?=?721) were ascertained from the Coronary Angiogram Database of South Australia (CADOSA). Women 50% stenosis in one or more coronary arteries at coronary angiography.

Results: Compared with women without a history of PCAD, women who were diagnosed with PCAD were more likely to have experienced the placenta-mediated pregnancy complications of preterm birth (adjusted odds ratio [OR]?=?2.46, 95% confidence interval [CI]: 1.21?5.00) or low-birth weight (adjusted OR?=?2.44, 95% CI: 1.22?4.88), or have been diagnosed with active asthma during pregnancy (adjusted OR?=?3.52, 95% CI: 1.05?11.76).

Conclusion: Placenta-mediated pregnancy complications should be recognized as clear risk markers for future PCAD.
Original languageEnglish
Pages (from-to)1208-1218
Number of pages11
JournalJOURNAL OF WOMENS HEALTH
Volume32
Issue number11
Early online date10 Oct 2023
DOIs
Publication statusPublished - 1 Nov 2023

Keywords

  • case-control study
  • data linkage
  • pregnancy complications
  • premature coronary artery disease
  • risk factors

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