Abstract
Background: There is increasing evidence that women who experience placenta-mediated pregnancy complications and gestational diabetes mellitus (GDM) are at higher risk for the development of coronary artery disease (CAD) later in life. We hypothesized that there is an association between placenta-mediated pregnancy complications, GDM, and risk of premature CAD (PCAD).
Methods: This research project involved a data linkage approach merging three databases of South Australian cohorts by using a retrospective, age-matched case?control study design. Cases (n?=?721) were ascertained from the Coronary Angiogram Database of South Australia (CADOSA). Women 50% stenosis in one or more coronary arteries at coronary angiography.
Results: Compared with women without a history of PCAD, women who were diagnosed with PCAD were more likely to have experienced the placenta-mediated pregnancy complications of preterm birth (adjusted odds ratio [OR]?=?2.46, 95% confidence interval [CI]: 1.21?5.00) or low-birth weight (adjusted OR?=?2.44, 95% CI: 1.22?4.88), or have been diagnosed with active asthma during pregnancy (adjusted OR?=?3.52, 95% CI: 1.05?11.76).
Conclusion: Placenta-mediated pregnancy complications should be recognized as clear risk markers for future PCAD.
Methods: This research project involved a data linkage approach merging three databases of South Australian cohorts by using a retrospective, age-matched case?control study design. Cases (n?=?721) were ascertained from the Coronary Angiogram Database of South Australia (CADOSA). Women 50% stenosis in one or more coronary arteries at coronary angiography.
Results: Compared with women without a history of PCAD, women who were diagnosed with PCAD were more likely to have experienced the placenta-mediated pregnancy complications of preterm birth (adjusted odds ratio [OR]?=?2.46, 95% confidence interval [CI]: 1.21?5.00) or low-birth weight (adjusted OR?=?2.44, 95% CI: 1.22?4.88), or have been diagnosed with active asthma during pregnancy (adjusted OR?=?3.52, 95% CI: 1.05?11.76).
Conclusion: Placenta-mediated pregnancy complications should be recognized as clear risk markers for future PCAD.
Original language | English |
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Pages (from-to) | 1208-1218 |
Number of pages | 11 |
Journal | JOURNAL OF WOMENS HEALTH |
Volume | 32 |
Issue number | 11 |
Early online date | 10 Oct 2023 |
DOIs | |
Publication status | Published - 1 Nov 2023 |
Keywords
- case-control study
- data linkage
- pregnancy complications
- premature coronary artery disease
- risk factors