Premature aging of cardiovascular/platelet function in polycystic ovarian syndrome

Wai Chan, Doan Ngo, Aaron Sverdlov, Sharmalar Rajendran, Irene Stafford, Tamila Heresztyn, Yuliy Chirkov, John Horowitz

    Research output: Contribution to journalArticlepeer-review

    13 Citations (Scopus)


    Objective: The objective of this study was to compare the impact of aging on nitric oxide (NO) modulation of platelet and vascular function in healthy women and women with polycystic ovary syndrome. Methods and Results: A case-control study of women ages 18 to 60 years, comparing women with polycystic ovarian syndrome against age-matched healthy controls, was performed. A total of 242 women, of whom 109 had polycystic ovarian syndrome (based on Rotterdam criteria), participated in the study. Women who were pregnant or on clopidogrel were excluded from the study. Inhibition of platelet aggregation by nitric oxide (primary outcome measure), vascular endothelial function, plasma concentrations of NG, NG-dimethyl-L-arginine (ADMA), endothelial progenitor cell count, and high-sensitivity C-reactive protein (markers of endothelial dysfunction and inflammation) were assessed. With increasing age in control women, there was progressive attenuation of platelet responses to NO, impairment of endothelial function, and elevation of ADMA levels (P ≤.001). Irrespective of age, women with polycystic ovarian syndrome exhibited greater impairment of all these parameters (all P <.05, 2-way analysis of variance) and demonstrated these anomalies earlier in life. Conclusions: Normal aging in women is associated with attenuation of NO-based signaling in platelets and blood vessels. In women with polycystic ovarian syndrome, these changes are present from early adult life and may contribute to premature atherogenesis.

    Original languageEnglish
    Pages (from-to)640.e1-640.e7
    Number of pages7
    JournalAmerican Journal of Medicine
    Issue number7
    Publication statusPublished - Jul 2013


    • Aging
    • Nitric oxide
    • Polycystic ovary syndrome
    • Women


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