Prephenate dehydrogenase, the first enzyme in the tyrosine branch of the aromatic pathway is subject to feedback inhibition by tyrosine and also to activation by phenylalanine. The arrangement of activated steps in aromatic amino acid biosynthesis suggests that control of the aromatic pathway is adapted to supply a greater flux of tyrosine than is required for vegetative growth. Mutation of the structural gene (pt) for chorismate mutase has no effect upon the control functions of prephenate dehydrogenase, indicating that these enzymes are not structurally associated in Neurospora.
|Number of pages||6|
|Journal||Biochemical and Biophysical Research Communications|
|Publication status||Published - 15 Aug 1969|