TY - JOUR
T1 - Prevalence and correlates of erectile dysfunction in men on chronic haemodialysis
T2 - A multinational cross-sectional study
AU - Collaborative Depression and Sexual dysfunction (CDS) in Hemodialysis Working Group
AU - Vecchio, Mariacristina
AU - Palmer, Suetonia
AU - De Berardis, Giorgia
AU - Craig, Jonathan
AU - Johnson, David
AU - Pellegrini, Fabio
AU - Nicolucci, Antonio
AU - Sciancalepore, Michela
AU - Saglimbene, Valeria
AU - Gargano, Letizia
AU - Bonifati, Carmen
AU - Ruospo, Marinella
AU - Navaneethan, Sankar D.
AU - Montinaro, Vincenzo
AU - Stroumza, Paul
AU - Zsom, Marianna
AU - Torok, Mariatta
AU - Celia, Eduardo
AU - Gelfman, Ruben
AU - Bednarek-Skublewska, Anna
AU - Dulawa, Jan
AU - Graziano, Giusi
AU - Lucisano, Giuseppe
AU - Gentile, Giorgio
AU - Ferrari, Juan Nin
AU - Santoro, Antonio
AU - Zucchelli, Annalisa
AU - Triolo, Giorgio
AU - Maffei, Stefano
AU - Hegbrant, Jörgen
AU - Wollheim, Charlotta
AU - De Cosmo, Salvatore
AU - Manfreda, Valeria M.
AU - Strippoli, Giovanni F.M.
AU - Rubio, D.
AU - Labonia, W.
AU - Prado, M.
AU - Vinockur, A.
AU - Paparone, R.
AU - Mato Mira, C.
AU - Penãlba, A.
AU - Gravielle, M.
AU - Mojico, E.
AU - Vargas, M.
AU - Tirado, S.
AU - Paz, M.
AU - Rodriguez, G.
AU - López, L.
AU - Beistegui, R.
AU - Bonelli, C.
AU - Arias, M.
AU - Coira, G.
AU - Florio, D.
AU - León, L.
AU - Hermida, O.
AU - Kapnik, S.
AU - García, K.
AU - De Francesco, J.
AU - Altman, H.
AU - Cravzoff, F.
AU - Mandri, S.
AU - Albert, K.
AU - Kassai, M.
AU - Kiss, E.
AU - Kosa, D.
AU - Orosz, A.
AU - Redl, J.
AU - Rozsahegyi, G.
AU - Varga, E.
AU - Vezekenyi, Zs
AU - Zajko, E.
AU - Bereczki, A.
AU - Czikos, L.
AU - Kuti, A.
AU - Mike, A.
AU - Steiner, K.
AU - Takacs, A.
AU - Tolnai, K.
AU - Toth, A.
AU - Ven, I.
AU - Mogyorosi, R.
AU - Ligeti, E.
AU - Dambrosio, N.
AU - Dagostino, F.
AU - Sambati, M. L.
AU - Giannoccaro, G.
AU - Greco, V.
AU - Di Toro Mammarella, R.
AU - Flammini, A.
AU - Boccia, E.
AU - Di Franco, D.
AU - Steri, P.
AU - Murgo, A. M.
AU - Fici, M.
AU - La Rosa, S.
AU - Montalto, G.
AU - Falco, M.
AU - Grisafi, F.
AU - Pagano, S.
AU - Amarù, S.
AU - Rallo, D.
AU - Conticello, A.
AU - Martucci, G.
AU - Sanfilippo, N.
AU - Leonardo, L.
AU - Liguigli, V. M.
AU - Matera, G.
AU - Saturno, C.
AU - Origlia, V.
AU - Paparella, G.
AU - D’Angelo, A.
AU - Falsitta, N.
AU - De Leo, G.
AU - Maldera, S.
AU - Riccardi, C.
AU - Pedone, F.
AU - Moscardelli, L.
AU - Mantuano, M.
AU - Lupo, A.
AU - Pellegrino, P. G.
AU - Antinoro, R.
AU - Cantarella, S.
AU - Randazzo, G.
AU - Marino, G.
AU - Meconizzi, M.
AU - Maniscalco, A.
AU - Donatelli, C.
AU - Torsello, F.
AU - Drobisz, M.
AU - Gregorczyk, T.
AU - Wyrwicz, G.
AU - Dżugan, W.
AU - Ostrowski, J.
AU - Zaluska, W.
AU - Bocheńska-Nowacka, E.
AU - Jaroszyński, A.
AU - Drabik, J.
AU - Birecka, M.
AU - Śliwarska-Strońska, J.
AU - Gauda, T.
AU - Dzimira, St
AU - Rutkowski, P.
AU - Lopes, J.
AU - Leal, M.
AU - Raimundol, M.
AU - Gabás, J.
AU - Pimato, M.
AU - Berti, P.
AU - Goro, L.
PY - 2012/6/1
Y1 - 2012/6/1
N2 - Background. Factors associated with erectile dysfunction in men on haemodialysis are incompletely identified due to suboptimal existing studies. We determined the prevalence and correlates of erectile dysfunction and identified combinations of clinical characteristics associated with a higher risk of erectile dysfunction using recursive partitioning and amalgamation (REPCAM) analysis. Methods. We conducted a multinational cross-sectional study in men on haemodialysis within a collaborative network. Erectile dysfunction and depressive symptoms were evaluated using the erectile function domain of the International Index of Erectile Function questionnaire and the Center for Epidemiological Studies-Depression Scale, respectively. Results. Nine hundred and forty-six (59%) of 1611 eligible men provided complete data for erectile dysfunction. Eighty-three per cent reported erectile dysfunction and 47% reported severe erectile dysfunction. Four per cent of those with erectile dysfunction were receiving pharmacological treatment. Depressive symptoms were the strongest correlate of erectile dysfunction [adjusted odds ratio 2.41 (95% confidence interval (CI) 1.57-3.71)]. Erectile dysfunction was also associated with age (1.06, 1.05-1.08), being unemployed (1.80, 1.17-2.79) or receiving a pension (2.05, 1.14-3.69) and interdialytic weight gain (1.9-2.87 kg, 1.92 [CI 1.19-3.09]; > 2.87 kg, 1.57 [CI 1.00-2.45]). Married men had a lower risk of erectile dysfunction (0.49, 0.31-0.76). The prevalence of erectile dysfunction was highest (94%) in unmarried and unemployed or retired men who have depressive symptoms. Conclusions. Most men on haemodialysis experience erectile dysfunction and are untreated. Given the prevalence of this condition and the relative lack of efficacy data for pharmacological agents, we suggest that large trials of pharmacological and non-pharmacological interventions for erectile dysfunction and depression are needed.
AB - Background. Factors associated with erectile dysfunction in men on haemodialysis are incompletely identified due to suboptimal existing studies. We determined the prevalence and correlates of erectile dysfunction and identified combinations of clinical characteristics associated with a higher risk of erectile dysfunction using recursive partitioning and amalgamation (REPCAM) analysis. Methods. We conducted a multinational cross-sectional study in men on haemodialysis within a collaborative network. Erectile dysfunction and depressive symptoms were evaluated using the erectile function domain of the International Index of Erectile Function questionnaire and the Center for Epidemiological Studies-Depression Scale, respectively. Results. Nine hundred and forty-six (59%) of 1611 eligible men provided complete data for erectile dysfunction. Eighty-three per cent reported erectile dysfunction and 47% reported severe erectile dysfunction. Four per cent of those with erectile dysfunction were receiving pharmacological treatment. Depressive symptoms were the strongest correlate of erectile dysfunction [adjusted odds ratio 2.41 (95% confidence interval (CI) 1.57-3.71)]. Erectile dysfunction was also associated with age (1.06, 1.05-1.08), being unemployed (1.80, 1.17-2.79) or receiving a pension (2.05, 1.14-3.69) and interdialytic weight gain (1.9-2.87 kg, 1.92 [CI 1.19-3.09]; > 2.87 kg, 1.57 [CI 1.00-2.45]). Married men had a lower risk of erectile dysfunction (0.49, 0.31-0.76). The prevalence of erectile dysfunction was highest (94%) in unmarried and unemployed or retired men who have depressive symptoms. Conclusions. Most men on haemodialysis experience erectile dysfunction and are untreated. Given the prevalence of this condition and the relative lack of efficacy data for pharmacological agents, we suggest that large trials of pharmacological and non-pharmacological interventions for erectile dysfunction and depression are needed.
KW - Depression
KW - Erectile dysfunction
KW - Haemodialysis
KW - Sexual function
UR - http://www.scopus.com/inward/record.url?scp=84861841598&partnerID=8YFLogxK
U2 - 10.1093/ndt/gfr635
DO - 10.1093/ndt/gfr635
M3 - Article
SN - 0931-0509
VL - 27
SP - 2479
EP - 2488
JO - Nephrology Dialysis Transplantation
JF - Nephrology Dialysis Transplantation
IS - 6
ER -