Prevalence and type of artefact with spectral domain optical coherence tomography macular ganglion cell imaging in glaucoma surveillance.

Mona Awadalla; Jude Fitzgerald; Nicholas Andrew; Tiger Zhou; Henry Marshall; Ayub Qassim; Mark Hassall; Robert Casson; Stuart Graham; Paul Healey; Ashish Agar; Anna Galanopoulos; Simon Phipps; Angela Chappell; John Landers; Jamie Craig

doi:10.1371/journal.pone.0206684

Prevalence and type of artefact with spectral domain optical coherence tomography macular ganglion cell imaging in glaucoma surveillance.

Mona Awadalla, Jude Fitzgerald, Nicholas Andrew, Tiger Zhou, Henry Marshall, Ayub Qassim, Mark Hassall, Robert Casson, Stuart Graham, Paul Healey, Ashish Agar, Anna Galanopoulos, Simon Phipps, Angela Chappell, John Landers, Jamie Craig

College of Medicine and Public Health

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Purpose The ganglion cell analysis (GCA) of the CIRRUS ^TM HD-OCT (Carl Zeiss, Meditec; Dublin, CA) provides measurement of the macular ganglion cell-inner plexiform layer (GCIPL) thickness. This study determined the frequency of scan artefacts and errors in GCIPL imaging in individuals undergoing HD-OCT surveillance for glaucoma. Method A total of 1439 eyes from 721 subjects enrolled in a prospective study assessing predictors of glaucoma progression underwent macular GCIPL imaging with the CIRRUS HD-OCT at recruitment. The prevalence of acquisition errors, segmentation errors, and co-morbid macular pathology was determined. Results A total of 87 (6.0%) of the 1439 scans had either acquisition errors, segmentation artefacts, or other macular pathology. The most common co-morbid macular pathology was epiretinal membrane in 2.2% of eyes. Conclusion The macular GCIPL scan was artefact free in 94% of eyes. However, epiretinal membrane and high myopia can cause scan artefact and should be considered when interpreting the results.

Original language	English
Article number	e0206684
Number of pages	9
Journal	PLoS One
Volume	13
Issue number	12
Early online date	2018
DOIs	https://doi.org/10.1371/journal.pone.0206684
Publication status	Published - Dec 2018

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Awadalla, M., Fitzgerald, J., Andrew, N., Zhou, T., Marshall, H., Qassim, A., Hassall, M., Casson, R., Graham, S., Healey, P., Agar, A., Galanopoulos, A., Phipps, S., Chappell, A., Landers, J., & Craig, J. (2018). Prevalence and type of artefact with spectral domain optical coherence tomography macular ganglion cell imaging in glaucoma surveillance. PLoS One, 13(12), Article e0206684. https://doi.org/10.1371/journal.pone.0206684

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title = "Prevalence and type of artefact with spectral domain optical coherence tomography macular ganglion cell imaging in glaucoma surveillance.",

abstract = " Purpose The ganglion cell analysis (GCA) of the CIRRUS TM HD-OCT (Carl Zeiss, Meditec; Dublin, CA) provides measurement of the macular ganglion cell-inner plexiform layer (GCIPL) thickness. This study determined the frequency of scan artefacts and errors in GCIPL imaging in individuals undergoing HD-OCT surveillance for glaucoma. Method A total of 1439 eyes from 721 subjects enrolled in a prospective study assessing predictors of glaucoma progression underwent macular GCIPL imaging with the CIRRUS HD-OCT at recruitment. The prevalence of acquisition errors, segmentation errors, and co-morbid macular pathology was determined. Results A total of 87 (6.0%) of the 1439 scans had either acquisition errors, segmentation artefacts, or other macular pathology. The most common co-morbid macular pathology was epiretinal membrane in 2.2% of eyes. Conclusion The macular GCIPL scan was artefact free in 94% of eyes. However, epiretinal membrane and high myopia can cause scan artefact and should be considered when interpreting the results. ",

author = "Mona Awadalla and Jude Fitzgerald and Nicholas Andrew and Tiger Zhou and Henry Marshall and Ayub Qassim and Mark Hassall and Robert Casson and Stuart Graham and Paul Healey and Ashish Agar and Anna Galanopoulos and Simon Phipps and Angela Chappell and John Landers and Jamie Craig",

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Awadalla, M, Fitzgerald, J, Andrew, N, Zhou, T, Marshall, H, Qassim, A, Hassall, M, Casson, R, Graham, S, Healey, P, Agar, A, Galanopoulos, A, Phipps, S, Chappell, A, Landers, J & Craig, J 2018, 'Prevalence and type of artefact with spectral domain optical coherence tomography macular ganglion cell imaging in glaucoma surveillance.', PLoS One, vol. 13, no. 12, e0206684. https://doi.org/10.1371/journal.pone.0206684

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T1 - Prevalence and type of artefact with spectral domain optical coherence tomography macular ganglion cell imaging in glaucoma surveillance.

AU - Awadalla, Mona

AU - Fitzgerald, Jude

AU - Andrew, Nicholas

AU - Zhou, Tiger

AU - Marshall, Henry

AU - Qassim, Ayub

AU - Hassall, Mark

AU - Casson, Robert

AU - Graham, Stuart

AU - Healey, Paul

AU - Agar, Ashish

AU - Galanopoulos, Anna

AU - Phipps, Simon

AU - Chappell, Angela

AU - Landers, John

AU - Craig, Jamie

PY - 2018/12

Y1 - 2018/12

N2 - Purpose The ganglion cell analysis (GCA) of the CIRRUS TM HD-OCT (Carl Zeiss, Meditec; Dublin, CA) provides measurement of the macular ganglion cell-inner plexiform layer (GCIPL) thickness. This study determined the frequency of scan artefacts and errors in GCIPL imaging in individuals undergoing HD-OCT surveillance for glaucoma. Method A total of 1439 eyes from 721 subjects enrolled in a prospective study assessing predictors of glaucoma progression underwent macular GCIPL imaging with the CIRRUS HD-OCT at recruitment. The prevalence of acquisition errors, segmentation errors, and co-morbid macular pathology was determined. Results A total of 87 (6.0%) of the 1439 scans had either acquisition errors, segmentation artefacts, or other macular pathology. The most common co-morbid macular pathology was epiretinal membrane in 2.2% of eyes. Conclusion The macular GCIPL scan was artefact free in 94% of eyes. However, epiretinal membrane and high myopia can cause scan artefact and should be considered when interpreting the results.

AB - Purpose The ganglion cell analysis (GCA) of the CIRRUS TM HD-OCT (Carl Zeiss, Meditec; Dublin, CA) provides measurement of the macular ganglion cell-inner plexiform layer (GCIPL) thickness. This study determined the frequency of scan artefacts and errors in GCIPL imaging in individuals undergoing HD-OCT surveillance for glaucoma. Method A total of 1439 eyes from 721 subjects enrolled in a prospective study assessing predictors of glaucoma progression underwent macular GCIPL imaging with the CIRRUS HD-OCT at recruitment. The prevalence of acquisition errors, segmentation errors, and co-morbid macular pathology was determined. Results A total of 87 (6.0%) of the 1439 scans had either acquisition errors, segmentation artefacts, or other macular pathology. The most common co-morbid macular pathology was epiretinal membrane in 2.2% of eyes. Conclusion The macular GCIPL scan was artefact free in 94% of eyes. However, epiretinal membrane and high myopia can cause scan artefact and should be considered when interpreting the results.

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JO - PLoS One

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ER -

Prevalence and type of artefact with spectral domain optical coherence tomography macular ganglion cell imaging in glaucoma surveillance.

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