Prevalence and type of artefact with spectral domain optical coherence tomography macular ganglion cell imaging in glaucoma surveillance.

Mona Awadalla, Jude Fitzgerald, Nicholas Andrew, Tiger Zhou, Henry Marshall, Ayub Qassim, Mark Hassall, Robert Casson, Stuart Graham, Paul Healey, Ashish Agar, Anna Galanopoulos, Simon Phipps, Angela Chappell, John Landers, Jamie Craig

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Abstract

Purpose The ganglion cell analysis (GCA) of the CIRRUS TM HD-OCT (Carl Zeiss, Meditec; Dublin, CA) provides measurement of the macular ganglion cell-inner plexiform layer (GCIPL) thickness. This study determined the frequency of scan artefacts and errors in GCIPL imaging in individuals undergoing HD-OCT surveillance for glaucoma. Method A total of 1439 eyes from 721 subjects enrolled in a prospective study assessing predictors of glaucoma progression underwent macular GCIPL imaging with the CIRRUS HD-OCT at recruitment. The prevalence of acquisition errors, segmentation errors, and co-morbid macular pathology was determined. Results A total of 87 (6.0%) of the 1439 scans had either acquisition errors, segmentation artefacts, or other macular pathology. The most common co-morbid macular pathology was epiretinal membrane in 2.2% of eyes. Conclusion The macular GCIPL scan was artefact free in 94% of eyes. However, epiretinal membrane and high myopia can cause scan artefact and should be considered when interpreting the results.

Original languageEnglish
Article numbere0206684
Number of pages9
JournalPLoS One
Volume13
Issue number12
Early online date2018
DOIs
Publication statusPublished - Dec 2018

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    Awadalla, M., Fitzgerald, J., Andrew, N., Zhou, T., Marshall, H., Qassim, A., Hassall, M., Casson, R., Graham, S., Healey, P., Agar, A., Galanopoulos, A., Phipps, S., Chappell, A., Landers, J., & Craig, J. (2018). Prevalence and type of artefact with spectral domain optical coherence tomography macular ganglion cell imaging in glaucoma surveillance. PLoS One, 13(12), [e0206684]. https://doi.org/10.1371/journal.pone.0206684