Prevention and treatment of renal disease in Henoch-Schönlein purpura: a systematic review

Wattana Chartapisak, S. L. Opastiraku, Narelle S. Willis, Jonathan C. Craig, Elisabeth M. Hodson

Research output: Contribution to journalReview article

72 Citations (Scopus)

Abstract

Objective: To determine the benefits and harms of therapies used to prevent or treat renal involvement in Henoch-Schönlein purpura.

Design: Systematic review of randomised controlled trials.

Setting: Secondary and tertiary paediatric and paediatric nephrology services.

Subjects: Ten trials involving 1230 children aged less than 18 years.

Main outcome measures: Persistent proteinuria and/or haematuria.

Results: Meta-analyses of four trials showed no significant difference in the risk of persistent kidney disease at 6 months (379 children; relative risk (RR) 0.51, 95% CI 0.24 to 1.11) and 12 months (498 children; RR 1.02, 95% CI 0.40 to 2.62) in children given prednisone for 14–28 days at presentation of Henoch-Schönlein purpura compared with placebo or supportive treatment. In children with severe renal disease, there was no significant difference in the risk of persistent renal disease with cyclophosphamide compared with supportive treatment (one trial; 56 children; RR 1.07, 95% CI 0.65 to 1.78) and with cyclosporin compared with methylprednisolone (one trial; 19 children; RR 0.39; 95% CI 0.14 to 1.06).

Conclusions: Data from randomised trials for any intervention used to improve renal outcomes in children with Henoch-Schönlein purpura are very sparse except for short-term prednisone, which has not been shown to be effective.
Original languageEnglish
Pages (from-to)132-137
Number of pages6
JournalArchives of Disease in Childhood
Volume94
Issue number2
DOIs
Publication statusPublished - 21 Jan 2009
Externally publishedYes

Keywords

  • Meta-analysis
  • renal treatment
  • Henoch-Schonlein Purpura (HSP)
  • paediatric nphrology

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