Prevention of Venous Thrombosis With Small, Subcutaneous Doses of Heparin

Alexander S. Gallus, Jack Hirsh, Stephen E. O'brien, John A. Mcbride, Robert J. Tuttle, Michael Gent

Research output: Contribution to journalArticlepeer-review

110 Citations (Scopus)


The effect of low-dose heparin prophylaxis on venous thrombosis and bleeding after major elective surgery was studied in a prospective controlled study of 820 patients. The total incidence of venous thrombosis detected with leg-scanning using fibrinogen labeled with radioactive iodine (125I) was reduced from 16.0% in the control group to 4.2% in treated patients. More important, the incidence of popliteal or femoral vein thrombosis was reduced from 2.9% to 1.0%. Prophylaxis resulted in a slight increase in bleeding—minor wound hematoma, mean volume of blood transfused, and a postoperative hematocrit fall in treated patients. However, increased bleeding was clinically minor, and prophylaxis was well tolerated.

Original languageEnglish
Pages (from-to)1980-1982
Number of pages3
JournalJAMA: The Journal of the American Medical Association
Issue number18
Publication statusPublished - 3 May 1976
Externally publishedYes


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