TY - JOUR
T1 - Prevention of Venous Thrombosis With Small, Subcutaneous Doses of Heparin
AU - Gallus, Alexander S.
AU - Hirsh, Jack
AU - O'brien, Stephen E.
AU - Mcbride, John A.
AU - Tuttle, Robert J.
AU - Gent, Michael
PY - 1976/5/3
Y1 - 1976/5/3
N2 - The effect of low-dose heparin prophylaxis on venous thrombosis and bleeding after major elective surgery was studied in a prospective controlled study of 820 patients. The total incidence of venous thrombosis detected with leg-scanning using fibrinogen labeled with radioactive iodine (125I) was reduced from 16.0% in the control group to 4.2% in treated patients. More important, the incidence of popliteal or femoral vein thrombosis was reduced from 2.9% to 1.0%. Prophylaxis resulted in a slight increase in bleeding—minor wound hematoma, mean volume of blood transfused, and a postoperative hematocrit fall in treated patients. However, increased bleeding was clinically minor, and prophylaxis was well tolerated.
AB - The effect of low-dose heparin prophylaxis on venous thrombosis and bleeding after major elective surgery was studied in a prospective controlled study of 820 patients. The total incidence of venous thrombosis detected with leg-scanning using fibrinogen labeled with radioactive iodine (125I) was reduced from 16.0% in the control group to 4.2% in treated patients. More important, the incidence of popliteal or femoral vein thrombosis was reduced from 2.9% to 1.0%. Prophylaxis resulted in a slight increase in bleeding—minor wound hematoma, mean volume of blood transfused, and a postoperative hematocrit fall in treated patients. However, increased bleeding was clinically minor, and prophylaxis was well tolerated.
UR - http://www.scopus.com/inward/record.url?scp=0017297384&partnerID=8YFLogxK
U2 - 10.1001/jama.1976.03260440032018
DO - 10.1001/jama.1976.03260440032018
M3 - Article
C2 - 946507
AN - SCOPUS:0017297384
VL - 235
SP - 1980
EP - 1982
JO - JAMA-Journal of The American Medical Association
JF - JAMA-Journal of The American Medical Association
SN - 0098-7484
IS - 18
ER -