Prior exposure to hyperglycaemia attenuates the relationship between glycaemic variability during critical illness and mortality

M. P. Plummer, M. E. Finnis, M. Horsfall, M. Ly, P. Kar, Y. A. Abdelhamid, A. M. Deane

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13 Citations (Scopus)

Abstract

Objective: Our primary objective was to determine the impact of prior exposure to hyperglycaemia on the association between glycaemic variability during critical illness and mortality. Our secondary objectives included evaluating the relationships between prior hyperglycaemia and hyperglycaemia or hypoglycaemia during critical illness and mortality.

Design and participants: A single-centre, retrospective, observational study in a tertiary intensive care unit. Patients admitted to the ICU between 1 September 2011 and 30 June 2015, with diabetes recorded using ICD-10-AM coding or a glycated haemoglobin (HbA 1c ) level of ≥ 6.5%, were stratified by prior hyperglycaemic level (HbA 1c < 6.5%, 6.5%-8.5%, or > 8.5%).

Main outcome measures: Glycaemic variability was assessed as the blood glucose coefficient of variation during the patient’s stay in the ICU. Multivariate logistic regression and marginal predictive plots were used to assess the impact of prior hyperglycaemia on the association between glycaemic metrics and mortality.

Results: We studied 1569 patients with diabetes (HbA 1c < 6.5%, n = 495; HbA 1c 6.5%-8.5%, n = 731; and HbA 1c > 8.5%, n = 343). Glycaemic variability was strongly associated with hospital mortality (P = 0.001), but this association showed a significant interaction with prior hyperglycaemia (P = 0.011), such that for patients with HbA 1c > 8.5%, increasing glycaemic variability was not associated with increased mortality. Acute hyperglycaemia was strongly associated with mortality (P < 0.0001) and also showed a significant interaction with prior hyperglycaemia (P = 0.001), such that for patients with HbA 1c > 8.5%, acute hyperglycaemia was not associated with mortality. Hypoglycaemia was also associated with mortality (P < 0.0001), but prior exposure to hyperglycaemia had a lesser effect on this relationship.

Conclusion: Prior exposure to hyperglycaemia attenuates the association between glycaemic variability and mortality in critically ill patients with diabetes.

Original languageEnglish
Pages (from-to)189-197
Number of pages9
JournalCritical Care and Resuscitation
Volume18
Issue number3
Publication statusPublished - 1 Sep 2016
Externally publishedYes

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    Plummer, M. P., Finnis, M. E., Horsfall, M., Ly, M., Kar, P., Abdelhamid, Y. A., & Deane, A. M. (2016). Prior exposure to hyperglycaemia attenuates the relationship between glycaemic variability during critical illness and mortality. Critical Care and Resuscitation, 18(3), 189-197.