TY - JOUR
T1 - Probabilistic interpretation of the Amelogenin locus
AU - Bright, Jo Anne
AU - Buckleton, John
AU - Taylor, Duncan
PY - 2021/5
Y1 - 2021/5
N2 - We describe a method to assign weights to genotype combinations at the Amelogenin locus. It is a typical practise in forensic laboratories that once the weight exceeds a threshold (such as 99 %), then they can be considered to be resolved enough to interpret (for example to load onto a database). We found that unless an individual is a clear major (or minor) contributor, the genotype weights do not typically exceed 99 % for any genotype. LRs have not been traditionally assigned for the Amelogenin locus and are small compared to an LR assigned for a modern day STR multiplex where, for a more discriminatory locus, the per locus LR for a resolved contributor could be in the order of tens or hundreds. The method described uses per contributor template values for a previously interpreted profile. The discrimination power is restricted, with a maximum possible LR of 2 for a fully resolved genotype, due to the limited number of alleles and hence genotypes and assuming equal proportions of genders in the population. However, it has a good power to exclude when the component is well resolved and non-concordant with a POI.
AB - We describe a method to assign weights to genotype combinations at the Amelogenin locus. It is a typical practise in forensic laboratories that once the weight exceeds a threshold (such as 99 %), then they can be considered to be resolved enough to interpret (for example to load onto a database). We found that unless an individual is a clear major (or minor) contributor, the genotype weights do not typically exceed 99 % for any genotype. LRs have not been traditionally assigned for the Amelogenin locus and are small compared to an LR assigned for a modern day STR multiplex where, for a more discriminatory locus, the per locus LR for a resolved contributor could be in the order of tens or hundreds. The method described uses per contributor template values for a previously interpreted profile. The discrimination power is restricted, with a maximum possible LR of 2 for a fully resolved genotype, due to the limited number of alleles and hence genotypes and assuming equal proportions of genders in the population. However, it has a good power to exclude when the component is well resolved and non-concordant with a POI.
KW - Amelogenin
KW - Deconvolution
KW - DNA profile
KW - Likelihood ratio
KW - Probabilistic genotyping
UR - http://www.scopus.com/inward/record.url?scp=85099338023&partnerID=8YFLogxK
U2 - 10.1016/j.fsigen.2021.102462
DO - 10.1016/j.fsigen.2021.102462
M3 - Article
AN - SCOPUS:85099338023
VL - 52
JO - Forensic Science International: Genetics
JF - Forensic Science International: Genetics
SN - 1872-4973
M1 - 102462
ER -