Probing the D-1,4,5-IP3/D-1,3,4,5-IP4 functional interface. Synthesis and pharmacology of novel D-3-modified myo-inositol trisphosphate analogues

Abdul H. Fauq, Alan P. Kozikowski, Vassil I. Ognyanov, Robert A. Wilcox, Stefan R. Nahorski

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

To explore the biological significance of the D-3 position phosphorylation of the second messenger D-myo-inositol 1,4,5-trisphosphate (IP3) in cellular signalling, three novel D-3-substituted analogues of IP3 have been synthesized; their binding and Ca2+-release profiles at the IP3-receptor have been studied and shown to correlate with the steric requirement of the D-3 substituent.

Original languageEnglish
Pages (from-to)1301-1302
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number11
DOIs
Publication statusPublished - 1994
Externally publishedYes

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