Probing the D-1,4,5-IP3/D-1,3,4,5-IP4 functional interface. Synthesis and pharmacology of novel D-3-modified myo-inositol trisphosphate analogues

Abdul H. Fauq; Alan P. Kozikowski; Vassil I. Ognyanov; Robert A. Wilcox; Stefan R. Nahorski

doi:10.1039/C39940001301

Probing the D-1,4,5-IP₃/D-1,3,4,5-IP₄ functional interface. Synthesis and pharmacology of novel D-3-modified myo-inositol trisphosphate analogues

Abdul H. Fauq
, Alan P. Kozikowski
, Vassil I. Ognyanov
, Robert A. Wilcox
, Stefan R. Nahorski

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

To explore the biological significance of the D-3 position phosphorylation of the second messenger D-myo-inositol 1,4,5-trisphosphate (IP₃) in cellular signalling, three novel D-3-substituted analogues of IP₃ have been synthesized; their binding and Ca²⁺-release profiles at the IP₃-receptor have been studied and shown to correlate with the steric requirement of the D-3 substituent.

Original language	English
Pages (from-to)	1301-1302
Number of pages	2
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	11
DOIs	https://doi.org/10.1039/C39940001301
Publication status	Published - 1994
Externally published	Yes

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title = "Probing the D-1,4,5-IP3/D-1,3,4,5-IP4 functional interface. Synthesis and pharmacology of novel D-3-modified myo-inositol trisphosphate analogues",

abstract = "To explore the biological significance of the D-3 position phosphorylation of the second messenger D-myo-inositol 1,4,5-trisphosphate (IP3) in cellular signalling, three novel D-3-substituted analogues of IP3 have been synthesized; their binding and Ca2+-release profiles at the IP3-receptor have been studied and shown to correlate with the steric requirement of the D-3 substituent.",

author = "Fauq, \{Abdul H.\} and Kozikowski, \{Alan P.\} and Ognyanov, \{Vassil I.\} and Wilcox, \{Robert A.\} and Nahorski, \{Stefan R.\}",

year = "1994",

doi = "10.1039/C39940001301",

language = "English",

pages = "1301--1302",

journal = "Journal of the Chemical Society, Chemical Communications",

issn = "0022-4936",

publisher = "Chemical Society",

number = "11",

}

Probing the D-1,4,5-IP₃/D-1,3,4,5-IP₄ functional interface. Synthesis and pharmacology of novel D-3-modified myo-inositol trisphosphate analogues. / Fauq, Abdul H.; Kozikowski, Alan P.; Ognyanov, Vassil I. et al.
In: Journal of the Chemical Society, Chemical Communications, No. 11, 1994, p. 1301-1302.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Probing the D-1,4,5-IP3/D-1,3,4,5-IP4 functional interface. Synthesis and pharmacology of novel D-3-modified myo-inositol trisphosphate analogues

AU - Fauq, Abdul H.

AU - Kozikowski, Alan P.

AU - Ognyanov, Vassil I.

AU - Wilcox, Robert A.

AU - Nahorski, Stefan R.

PY - 1994

Y1 - 1994

N2 - To explore the biological significance of the D-3 position phosphorylation of the second messenger D-myo-inositol 1,4,5-trisphosphate (IP3) in cellular signalling, three novel D-3-substituted analogues of IP3 have been synthesized; their binding and Ca2+-release profiles at the IP3-receptor have been studied and shown to correlate with the steric requirement of the D-3 substituent.

AB - To explore the biological significance of the D-3 position phosphorylation of the second messenger D-myo-inositol 1,4,5-trisphosphate (IP3) in cellular signalling, three novel D-3-substituted analogues of IP3 have been synthesized; their binding and Ca2+-release profiles at the IP3-receptor have been studied and shown to correlate with the steric requirement of the D-3 substituent.

UR - https://www.scopus.com/pages/publications/0028235539

U2 - 10.1039/C39940001301

DO - 10.1039/C39940001301

M3 - Article

AN - SCOPUS:0028235539

SN - 0022-4936

SP - 1301

EP - 1302

JO - Journal of the Chemical Society, Chemical Communications

JF - Journal of the Chemical Society, Chemical Communications

IS - 11

ER -

Probing the D-1,4,5-IP₃/D-1,3,4,5-IP₄ functional interface. Synthesis and pharmacology of novel D-3-modified myo-inositol trisphosphate analogues

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