Production of [14C]Acetylcholine and [14C]Carbon Dioxide from [U–14C]Glucose in Tissue Prisms from Aging Rat Brain

N. R. Sims, K. L. Marek, D. M. Bowen, A. N. Davison

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48 Citations (Scopus)


Abstract: Production of [14C]acetylcholine and 14CO2 was examined by using tissue prisms from neocortex, hippocampus, and striatum from rats aged approximately 5 months, 13 months, and 27 months. [14C]Acetylcholine synthesis in the striatum showed highly significant decreases with age for measurements in the presence of both 5 mm‐ and 31 mm‐K+, contrasting with the lack of significant change in 14CO2 production in this region. The neocortex and hippocampus showed only small changes, especially when comparison was made between 13‐month and senescent animals. Measurements of the release of [14C]acetylcholine and influence of atropine on this release confirmed the relative stability with age of the cholinergic system in the neocortex.

Original languageEnglish
Pages (from-to)488-492
Number of pages5
JournalJournal of Neurochemistry
Issue number2
Publication statusPublished - Feb 1982
Externally publishedYes


  • Acetylcholine synthesis
  • Aging
  • Glucose metabolism


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