Prognostic Value of 18F-Fluoro-Deoxyglucose-Positron Emission Tomography Volumetric Parameters in Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma

Anthony Noor, Manish Mair, Lachlan Cook, Harrison Bolt, Sanith Cheriyan, Charmaine M. Woods, James Hopkins, Eng H. Ooi

Research output: Contribution to journalArticlepeer-review

Abstract

Background: This study evaluates and compares the prognostic significance of 18F-fluoro-deoxyglucose-positron emission tomography (18F-FDG PET) volumetric parameters in human papillomavirus-related oropharyngeal squamous cell carcinoma (OPSCC). 

Methods: A retrospective review of all patients treated for OPSCC with curative intent between 2012 and 2018 was performed. Volumetric parameters analyzed included the maximum standardized uptake value (SUVmax), SUVpeak, metabolic tumor volume (MTV), and total lesion glycolysis (TLG) in both the primary tumor and nodal metastases. Prognostic significance was determined using Cox proportional hazards models for disease-free survival (DFS) and overall survival (OS). 

Results: Primary tumor MTV and TLG significantly correlated with both DFS and OS however the commonly reported SUVmax was not found to be predictive. Nodal measures of SUVmax, MTV, and TLG were not significant predictors of survival outcomes. 

Conclusion: A higher burden of metabolically active primary tumor as measured on volumetric 18F-FDG PET parameters is associated with poorer DFS and OS. This improved prognostication may be used to counsel patients and select those appropriate for treatment de-escalation in the future. 

Level of Evidence: Level 3 Laryngoscope, 2022.

Original languageEnglish
Number of pages6
JournalLaryngoscope
Early online date26 Aug 2022
DOIs
Publication statusE-pub ahead of print - 26 Aug 2022

Keywords

  • evidence-based medicine
  • neck
  • oropharynx

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