Programmed Cell Death Protein 1 (PD-1)-Expressing CD4+ T Cells Are Expanded in Early Rheumatoid Arthritis and Correlate with Response to Treatment

Katie Williams, Annabelle Small, Qingxuan Song, Suzanne Cole, Ling-Yang Hao, William Murray-Brown, Susanna Proudman, Malcolm Smith, Sunil Nagpal, Mihir Wechalekar

Research output: Contribution to conferenceAbstractpeer-review

Abstract

Background/Purpose: Programmed death protein 1 (PD-1) expressing T cells, including T follicular and T peripheral helper cells, are expanded in the circulation of individuals with rheumatoid arthritis (RA). Despite this, the origins of these cells and their functional role in RA remain poorly understood. To address this, we sought to investigate the genetic profiles of PD-1-expressing lymphocytes of the peripheral blood and synovial infiltrate of patients with early RA, and to characterise these cells in disease.
Original languageEnglish
Number of pages2
Publication statusPublished - 2021
EventAmerican College of Rheumatology Convergence 2021 - Virtual, United States
Duration: 5 Nov 20219 Nov 2021

Conference

ConferenceAmerican College of Rheumatology Convergence 2021
Abbreviated titleACR Convergence 2021
Country/TerritoryUnited States
Period5/11/219/11/21

Keywords

  • Rheumatoid arthritis
  • Programmed cell death
  • Treatments

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