Progressive cranial neuropathy and uterine involvement in myeloid sarcoma

Anthony Khoo, Thomas Kimber, Penelope Cohen, Roula Ghaoui

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Abstract

A rare extramedullary manifestation of haematological malignancy, myeloid sarcoma is most commonly seen in patients with acute myeloid leukaemia. We report on an adult patient who presented with an atypical phenotype of progressive cranial neuropathy without blood or bone marrow involvement, and in whom obtaining material for pathological diagnosis was made challenging by unusual findings of absent fluorodeoxyglucose-positron emission tomography avidity and involvement of sites not readily accessible to biopsy (orbital apex and cauda equina). The eventual diagnosis was obtained through biopsy of the uterine cervix before being verified on repeat lymph node and cerebrospinal fluid sampling prior to initiation of chemotherapy.

Original languageEnglish
Article numbere000006
Number of pages3
JournalBMJ Neurology Open
Volume1
Issue number1
DOIs
Publication statusPublished - Jul 2019

Keywords

  • Myeloid sarcoma
  • Leukaemia
  • Case report

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