Projections and chemical coding of neurons with immunoreactivity for nitric oxide synthase in the guinea-pig small intestine

M. Costa, J. B. Furness, S. Pompolo, S. J.H. Brookes, J. C. Bornstein, D. S. Bredt, S. H. Snyder

    Research output: Contribution to journalArticle

    280 Citations (Scopus)

    Abstract

    The distribution of nitric oxide synthase (NOS) immunoreactivity was investigated in the guinea-pig small intestine. There were many immunoreactive nerve cell bodies in the myenteric plexus but very few in submucous ganglia. NOS immunoreactivity was not found in non-neuronal cells except for rare mucosal endocrine cells. Abundant immunoreactive nerve fibres in both myenteric and submucous ganglia, and in the circular muscle, arose from myenteric nerve cells whose axons projected anally along the intestine. NOS immunoreactivity coexisted with VIP-immunoreactivity, but not with substance P immunoreactivity. We conclude that nitric oxide synthase is located in a sub-population of enteric neurons, amongst which are inhibitory motor neurons that supply the circular muscle layer.

    Original languageEnglish
    Pages (from-to)121-125
    Number of pages5
    JournalNeuroscience letters
    Volume148
    Issue number1-2
    DOIs
    Publication statusPublished - 14 Dec 1992

    Keywords

    • Enteric nervous system
    • Guinea-pig
    • Myenteric plexus
    • Nitric oxide synthase
    • Small intestine
    • Submucous plexus

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