TY - JOUR
T1 - Prolonged remission of chronic reactive arthritis treated with three infusions of infliximab
AU - Wechalekar, Mihir
AU - Rischmueller, Maureen
AU - Whittle, Samuel
AU - Burnet, Simon
AU - Hill, Catherine
PY - 2010/3
Y1 - 2010/3
N2 - Reactive arthritis is generally self-remitting but can be chronic. Predictors of chronicity include HLA B27 positivity and triggering infections with Yersinia, Salmonella, Shigella, or Chlamydia. Nonsteroidal antiinflammatory drugs and local steroids are the mainstays, with some evidence for disease modifying antirheumatic drugs. Limited evidence suggests effectiveness of tumor necrosis factor antagonists. We report the case of reactive arthritis following a Chlamydia urinary tract infection progressing to a chronic course, treated with a short course of high dose tumor necrosis factor antagonist, followed up for over 2 years with prolonged remission, allowing discontinuation of disease modifying antirheumatic drug therapy.
AB - Reactive arthritis is generally self-remitting but can be chronic. Predictors of chronicity include HLA B27 positivity and triggering infections with Yersinia, Salmonella, Shigella, or Chlamydia. Nonsteroidal antiinflammatory drugs and local steroids are the mainstays, with some evidence for disease modifying antirheumatic drugs. Limited evidence suggests effectiveness of tumor necrosis factor antagonists. We report the case of reactive arthritis following a Chlamydia urinary tract infection progressing to a chronic course, treated with a short course of high dose tumor necrosis factor antagonist, followed up for over 2 years with prolonged remission, allowing discontinuation of disease modifying antirheumatic drug therapy.
KW - Reactive arthritis
KW - TNF antagonists
UR - http://www.scopus.com/inward/record.url?scp=77949484278&partnerID=8YFLogxK
U2 - 10.1097/RHU.0b013e3181d06f70
DO - 10.1097/RHU.0b013e3181d06f70
M3 - Article
VL - 16
SP - 79
EP - 80
JO - JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
JF - JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
SN - 1076-1608
IS - 2
ER -