Propolis from Different Geographic Origins Decreases Intestinal Inflammation and Bacteroides spp. Populations in a Model of DSS-Induced Colitis

Kai Wang, Xiaolu Jin, Qiangqiang Li, Alexandra Christine Helena Frankland Sawaya, Richard K. Le Leu, Michael A. Conlon, Liming Wu, Fuliang Hu

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Scope: Dietary supplementation with polyphenol-rich propolis can protect against experimentally induced colitis. We examined whether different polyphenol compositions of Chinese propolis (CP) and Brazilian propolis (BP) influence their ability to protect against dextran sulfate sodium (DSS)-induced colitis in rats. Methods and results: HPLC-DAD/Q-TOF-MS analysis confirmed that polyphenol compositions of CP and BP were dissimilar. Rats were given CP or BP by gavage (300 mg kg−1 body weight) throughout the study, starting 1 week prior to DSS treatment for 1 week followed by 3 d without DSS. CP and BP significantly reduced the colitis disease activity index relative to controls not receiving propolis, prevented significant DSS-induced colonic tissue damage, and increased resistance to DSS-induced colonic oxidative stress as shown by reduced malonaldehyde levels and increased T-AOC levels. CP and BP significantly reduced DSS-induced colonic apoptosis. Colonic inflammatory markers IL-1β, IL-6, and MCP-1 were suppressed by CP and BP, whereas only BP-induced expression of TGF-β. CP, not BP, increased the diversity and richness of gut microbiota populations. Both forms of propolis significantly reduced populations of Bacteroides spp. Conclusions: Despite the dissimilar polyphenol compositions of CP and BP, their ability to protect against DSS-induced colitis is similar. Nevertheless, some different physiological impacts were observed.

Original languageEnglish
Article number1800080
Number of pages11
JournalMolecular Nutrition and Food Research
Volume62
Issue number17
DOIs
Publication statusPublished - Sep 2018
Externally publishedYes

Keywords

  • Bacteroides spp
  • colitis
  • gut microbiota
  • polyphenols
  • propolis

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