Prospects in the Total Synthesis of Protein Therapeutics

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    22 Citations (Scopus)


    Protein therapeutics are gaining headway in the treatment and prevention of a variety of maladies. Critical to the success and growing use of biologic-level pharmaceuticals is the development of methods for their precise synthesis. This review highlights the emerging techniques for the total synthesis of proteins, with a special focus on the possibility of accessing therapeutic targets through chemoselective peptide ligations.

    Original languageEnglish
    Pages (from-to)122-135
    Number of pages14
    JournalChemical Biology and Drug Design
    Issue number1
    Publication statusPublished - Jan 2013


    • Biologic
    • Biopharmaceutical
    • Native chemical ligation
    • Peptide ligation
    • Protein synthesis
    • Protein therapeutic


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