Prospects in the Total Synthesis of Protein Therapeutics

Justin Chalker

doi:10.1111/cbdd.12007

Prospects in the Total Synthesis of Protein Therapeutics

Justin Chalker

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Protein therapeutics are gaining headway in the treatment and prevention of a variety of maladies. Critical to the success and growing use of biologic-level pharmaceuticals is the development of methods for their precise synthesis. This review highlights the emerging techniques for the total synthesis of proteins, with a special focus on the possibility of accessing therapeutic targets through chemoselective peptide ligations.

Original language	English
Pages (from-to)	122-135
Number of pages	14
Journal	Chemical Biology and Drug Design
Volume	81
Issue number	1
DOIs	https://doi.org/10.1111/cbdd.12007
Publication status	Published - Jan 2013

Keywords

Biologic
Biopharmaceutical
Native chemical ligation
Peptide ligation
Protein synthesis
Protein therapeutic

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10.1111/cbdd.12007

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Prospects in the Total Synthesis of Protein Therapeutics

Abstract

Keywords

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