Prostaglandins and Leukotrienes

G. E. Caughey; M. J. James; L. G. Cleland

doi:10.1016/B978-0-12-375083-9.00238-5

Prostaglandins and Leukotrienes

G. E. Caughey, M. J. James, L. G. Cleland

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Prostaglandins (PGs) and leukotrienes are lipid mediators belonging to the eicosanoid family. They are synthesized from arachidonic acid, a polyunsaturated fatty acid, via a tightly regulated pathway. A key enzyme in the synthetic pathway, cyclooxygenase, has been the target for the pharmacological modulation of PG-mediated clinical manifestations. Eicosanoids generally act as paracrine or autocrine agents and are involved in the maintenance of homeostatic processes as well as in the pathophysiology of several chronic diseases.

Original language	English
Title of host publication	Encyclopedia of Human Nutrition
Publisher	Elsevier Inc.
Pages	104-110
Number of pages	7
Volume	4-4
Edition	3rd
ISBN (Electronic)	9780123848857
ISBN (Print)	9780123750839
DOIs	https://doi.org/10.1016/B978-0-12-375083-9.00238-5
Publication status	Published - 2013
Externally published	Yes

Keywords

Arachidonic acid
Cyclooxygenase
Eicosanoids
Leukotrienes
Lipoxygenase
Prostaglandin

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title = "Prostaglandins and Leukotrienes",

abstract = "Prostaglandins (PGs) and leukotrienes are lipid mediators belonging to the eicosanoid family. They are synthesized from arachidonic acid, a polyunsaturated fatty acid, via a tightly regulated pathway. A key enzyme in the synthetic pathway, cyclooxygenase, has been the target for the pharmacological modulation of PG-mediated clinical manifestations. Eicosanoids generally act as paracrine or autocrine agents and are involved in the maintenance of homeostatic processes as well as in the pathophysiology of several chronic diseases.",

keywords = "Arachidonic acid, Cyclooxygenase, Eicosanoids, Leukotrienes, Lipoxygenase, Prostaglandin",

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T1 - Prostaglandins and Leukotrienes

AU - Caughey, G. E.

AU - James, M. J.

AU - Cleland, L. G.

PY - 2013

Y1 - 2013

N2 - Prostaglandins (PGs) and leukotrienes are lipid mediators belonging to the eicosanoid family. They are synthesized from arachidonic acid, a polyunsaturated fatty acid, via a tightly regulated pathway. A key enzyme in the synthetic pathway, cyclooxygenase, has been the target for the pharmacological modulation of PG-mediated clinical manifestations. Eicosanoids generally act as paracrine or autocrine agents and are involved in the maintenance of homeostatic processes as well as in the pathophysiology of several chronic diseases.

AB - Prostaglandins (PGs) and leukotrienes are lipid mediators belonging to the eicosanoid family. They are synthesized from arachidonic acid, a polyunsaturated fatty acid, via a tightly regulated pathway. A key enzyme in the synthetic pathway, cyclooxygenase, has been the target for the pharmacological modulation of PG-mediated clinical manifestations. Eicosanoids generally act as paracrine or autocrine agents and are involved in the maintenance of homeostatic processes as well as in the pathophysiology of several chronic diseases.

KW - Arachidonic acid

KW - Cyclooxygenase

KW - Eicosanoids

KW - Leukotrienes

KW - Lipoxygenase

KW - Prostaglandin

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DO - 10.1016/B978-0-12-375083-9.00238-5

M3 - Chapter

AN - SCOPUS:85043299109

SN - 9780123750839

VL - 4-4

SP - 104

EP - 110

BT - Encyclopedia of Human Nutrition

PB - Elsevier Inc.

ER -

Prostaglandins and Leukotrienes

Abstract

Keywords

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