The plasma membrane (PM) and endocytic protein quality control (QC) in conjunction with the endosomal sorting machinery either repairs or targets conformationally damaged membrane proteins for lysosomal/vacuolar degradation. Here, we provide an overview of emerging aspects of the underlying mechanisms of PM QC that fulfill a critical role in preserving cellular protein homeostasis in health and diseases.
- Decoding Ubiquitin Modification
- Endocytic Pathway
- Nonnative PM Proteins
- Chaperone-Independent Ubiquitination
- Transmembrane Segment Recognition
- Conformational Surveillance of PM Proteins