Protein homeostasis at the plasma membrane

Pirjo M. Apaja; Gergely L. Lukacs

doi:10.1152/physiol.00058.2013

Protein homeostasis at the plasma membrane

Pirjo M. Apaja, Gergely L. Lukacs

Research output: Contribution to journal › Review article › peer-review

39 Citations (Scopus)

Abstract

The plasma membrane (PM) and endocytic protein quality control (QC) in conjunction with the endosomal sorting machinery either repairs or targets conformationally damaged membrane proteins for lysosomal/vacuolar degradation. Here, we provide an overview of emerging aspects of the underlying mechanisms of PM QC that fulfill a critical role in preserving cellular protein homeostasis in health and diseases.

Original language	English
Pages (from-to)	265-277
Number of pages	13
Journal	Physiology
Volume	29
Issue number	4
DOIs	https://doi.org/10.1152/physiol.00058.2013
Publication status	Published - Jul 2014
Externally published	Yes

Keywords

Decoding Ubiquitin Modification
Endocytic Pathway
Nonnative PM Proteins
Chaperone-Independent Ubiquitination
Transmembrane Segment Recognition
Conformational Surveillance of PM Proteins

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10.1152/physiol.00058.2013Licence: In Copyright

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KW - Decoding Ubiquitin Modification

KW - Endocytic Pathway

KW - Nonnative PM Proteins

KW - Chaperone-Independent Ubiquitination

KW - Transmembrane Segment Recognition

KW - Conformational Surveillance of PM Proteins

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JO - Physiology

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Protein homeostasis at the plasma membrane

Abstract

Keywords

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