Protein homeostasis at the plasma membrane

Pirjo M. Apaja, Gergely L. Lukacs

Research output: Contribution to journalReview articlepeer-review

38 Citations (Scopus)


The plasma membrane (PM) and endocytic protein quality control (QC) in conjunction with the endosomal sorting machinery either repairs or targets conformationally damaged membrane proteins for lysosomal/vacuolar degradation. Here, we provide an overview of emerging aspects of the underlying mechanisms of PM QC that fulfill a critical role in preserving cellular protein homeostasis in health and diseases.

Original languageEnglish
Pages (from-to)265-277
Number of pages13
Issue number4
Publication statusPublished - Jul 2014
Externally publishedYes


  • Decoding Ubiquitin Modification
  • Endocytic Pathway
  • Nonnative PM Proteins
  • Chaperone-Independent Ubiquitination
  • Transmembrane Segment Recognition
  • Conformational Surveillance of PM Proteins


Dive into the research topics of 'Protein homeostasis at the plasma membrane'. Together they form a unique fingerprint.

Cite this