Protein homeostasis at the plasma membrane

Pirjo M. Apaja, Gergely L. Lukacs

Research output: Contribution to journalReview articlepeer-review

22 Citations (Scopus)

Abstract

The plasma membrane (PM) and endocytic protein quality control (QC) in conjunction with the endosomal sorting machinery either repairs or targets conformationally damaged membrane proteins for lysosomal/vacuolar degradation. Here, we provide an overview of emerging aspects of the underlying mechanisms of PM QC that fulfill a critical role in preserving cellular protein homeostasis in health and diseases.

Original languageEnglish
Pages (from-to)265-277
Number of pages13
JournalPhysiology
Volume29
Issue number4
DOIs
Publication statusPublished - Jul 2014
Externally publishedYes

Keywords

  • Decoding Ubiquitin Modification
  • Endocytic Pathway
  • Nonnative PM Proteins
  • Chaperone-Independent Ubiquitination
  • Transmembrane Segment Recognition
  • Conformational Surveillance of PM Proteins

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