Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?: Neuronal life, growth and death signalling are crucially regulated by intra-membrane proteolysis and trafficking of p75NTR

Sune Skeldal, Dusan Matusica, A Nykjaer, Elizabeth Coulson

    Research output: Contribution to journalArticle

    72 Citations (Scopus)

    Abstract

    The common neurotrophin receptor (p75NTR) regulates various functions in the developing and adult nervous system. Cell survival, cell death, axonal and growth cone retraction, and regulation of the cell cycle can be regulated by p75NTR-mediated signals following activation by either mature or pro-neurotrophins and in combination with various co-receptors, including Trk receptors and sortilin. Here, we review the known functions of p75NTR by cell type, receptor-ligand combination, and whether regulated intra-membrane proteolysis of p75NTR is required for signalling. We highlight that the generation of the intracellular domain fragment of p75NTR is associated with many of the receptor functions, regardless of its ligand and co-receptor interactions.

    Original languageEnglish
    Pages (from-to)614-625
    Number of pages12
    JournalBIOESSAYS
    Volume33
    Issue number8
    DOIs
    Publication statusPublished - 2011

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