Proton pump inhibitors are not associated with inflammatory myopathies: A case control study

Thomas Khoo; Gillian E. Caughey; Catherine Hill; Vidya Limaye

doi:10.1002/mus.26336

Proton pump inhibitors are not associated with inflammatory myopathies: A case control study

Thomas Khoo, Gillian E. Caughey, Catherine Hill, Vidya Limaye

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Introduction: A rare association of proton pump inhibitor (PPI) use with the development of inflammatory myopathies (IM) has been reported, but, unlike with statin medications, there is limited data supporting or refuting this observation. Methods: A case-control study was conducted on patients with IM. Clinical information, medications, and demographics were recorded. Controls were matched 3:1 for age and gender. Results: Two hundred twenty-one cases of IM were identified. No association of PPI use with IM was observed when compared with controls (odds ratio 1.04 [95% confidence interval 0.68–1.58]) and similar results were observed after adjusting for diabetes, cardiovascular disease, and statin exposure (adjusted odds ratio 1.084 [95% confidence interval 0.69–1.70]). There was no association of any histologic subtype of IM with PPI exposure. Discussion: Our findings do not support an association of PPI exposure with IM. Co-prescription of PPI with other medications was not considered and could be further investigated with larger cohorts.

Original language	English
Pages (from-to)	855-857
Number of pages	3
Journal	Muscle and Nerve
Volume	58
Issue number	6
DOIs	https://doi.org/10.1002/mus.26336
Publication status	Published - Dec 2018
Externally published	Yes

Keywords

drug side effect
inflammatory myopathy
myositis
proton pump inhibitors
statin

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title = "Proton pump inhibitors are not associated with inflammatory myopathies: A case control study",

abstract = "Introduction: A rare association of proton pump inhibitor (PPI) use with the development of inflammatory myopathies (IM) has been reported, but, unlike with statin medications, there is limited data supporting or refuting this observation. Methods: A case-control study was conducted on patients with IM. Clinical information, medications, and demographics were recorded. Controls were matched 3:1 for age and gender. Results: Two hundred twenty-one cases of IM were identified. No association of PPI use with IM was observed when compared with controls (odds ratio 1.04 [95% confidence interval 0.68–1.58]) and similar results were observed after adjusting for diabetes, cardiovascular disease, and statin exposure (adjusted odds ratio 1.084 [95% confidence interval 0.69–1.70]). There was no association of any histologic subtype of IM with PPI exposure. Discussion: Our findings do not support an association of PPI exposure with IM. Co-prescription of PPI with other medications was not considered and could be further investigated with larger cohorts. ",

keywords = "drug side effect, inflammatory myopathy, myositis, proton pump inhibitors, statin",

author = "Thomas Khoo and Caughey, {Gillian E.} and Catherine Hill and Vidya Limaye",

year = "2018",

month = dec,

doi = "10.1002/mus.26336",

language = "English",

volume = "58",

pages = "855--857",

journal = "Muscle and Nerve",

issn = "0148-639X",

publisher = "John Wiley & Sons, Inc",

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TY - JOUR

T1 - Proton pump inhibitors are not associated with inflammatory myopathies

T2 - A case control study

AU - Khoo, Thomas

AU - Caughey, Gillian E.

AU - Hill, Catherine

AU - Limaye, Vidya

PY - 2018/12

Y1 - 2018/12

N2 - Introduction: A rare association of proton pump inhibitor (PPI) use with the development of inflammatory myopathies (IM) has been reported, but, unlike with statin medications, there is limited data supporting or refuting this observation. Methods: A case-control study was conducted on patients with IM. Clinical information, medications, and demographics were recorded. Controls were matched 3:1 for age and gender. Results: Two hundred twenty-one cases of IM were identified. No association of PPI use with IM was observed when compared with controls (odds ratio 1.04 [95% confidence interval 0.68–1.58]) and similar results were observed after adjusting for diabetes, cardiovascular disease, and statin exposure (adjusted odds ratio 1.084 [95% confidence interval 0.69–1.70]). There was no association of any histologic subtype of IM with PPI exposure. Discussion: Our findings do not support an association of PPI exposure with IM. Co-prescription of PPI with other medications was not considered and could be further investigated with larger cohorts.

AB - Introduction: A rare association of proton pump inhibitor (PPI) use with the development of inflammatory myopathies (IM) has been reported, but, unlike with statin medications, there is limited data supporting or refuting this observation. Methods: A case-control study was conducted on patients with IM. Clinical information, medications, and demographics were recorded. Controls were matched 3:1 for age and gender. Results: Two hundred twenty-one cases of IM were identified. No association of PPI use with IM was observed when compared with controls (odds ratio 1.04 [95% confidence interval 0.68–1.58]) and similar results were observed after adjusting for diabetes, cardiovascular disease, and statin exposure (adjusted odds ratio 1.084 [95% confidence interval 0.69–1.70]). There was no association of any histologic subtype of IM with PPI exposure. Discussion: Our findings do not support an association of PPI exposure with IM. Co-prescription of PPI with other medications was not considered and could be further investigated with larger cohorts.

KW - drug side effect

KW - inflammatory myopathy

KW - myositis

KW - proton pump inhibitors

KW - statin

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U2 - 10.1002/mus.26336

DO - 10.1002/mus.26336

M3 - Article

C2 - 30192022

AN - SCOPUS:85055122142

SN - 0148-639X

VL - 58

SP - 855

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JO - Muscle and Nerve

JF - Muscle and Nerve

IS - 6

ER -

Proton pump inhibitors are not associated with inflammatory myopathies: A case control study

Abstract

Keywords

UN SDGs

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