TY - JOUR
T1 - Pulmonary effects of chronic elevation in microvascular pressure differ between hypertension and myocardial infarct induced heart failure
AU - Dixon, Dani
AU - Griggs, Kim
AU - De Pasquale, Carmine
AU - Bersten, Andrew
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Background: Chronic heart failure (CHF) following coronary artery ligation and myocardial infarction in the rat leads to a homeostatic reduction in surface tension with associated alveolar type II cell hyperplasia and increased surfactant content, which functionally compensates for pulmonary collagen deposition and increased tissue stiffness. To differentiate the effects on lung remodelling of the sudden rise in pulmonary microvascular pressure (Pmv) with myocardial infarction from its consequent chronic elevation, we examined a hypertensive model of CHF. Methods: Cardiopulmonary outcomes due to chronic pulmonary capillary hypertension were assessed at six and 15 weeks following abdominal aortic banding (AAB) in the rat. Results: At six weeks post-surgery, despite significantly elevated left ventricular end-diastolic pressure, myocardial hypertrophy and increased left ventricular internal circumference in AAB rats compared with sham operated controls (p. ≤. 0.003), lung weights and tissue composition remained unchanged, and lung compliance was normal. At 15 weeks post-surgery increased lung oedema was evident in AAB rats (p. =. 0.002) without decreased lung compliance or evidence of tissue remodelling. Conclusion: Despite chronically elevated Pmv, comparable to that resulting from past myocardial infarction (LVEDP. >. 19. mmHg), there is no evidence of pulmonary remodelling in the AAB model of CHF.
AB - Background: Chronic heart failure (CHF) following coronary artery ligation and myocardial infarction in the rat leads to a homeostatic reduction in surface tension with associated alveolar type II cell hyperplasia and increased surfactant content, which functionally compensates for pulmonary collagen deposition and increased tissue stiffness. To differentiate the effects on lung remodelling of the sudden rise in pulmonary microvascular pressure (Pmv) with myocardial infarction from its consequent chronic elevation, we examined a hypertensive model of CHF. Methods: Cardiopulmonary outcomes due to chronic pulmonary capillary hypertension were assessed at six and 15 weeks following abdominal aortic banding (AAB) in the rat. Results: At six weeks post-surgery, despite significantly elevated left ventricular end-diastolic pressure, myocardial hypertrophy and increased left ventricular internal circumference in AAB rats compared with sham operated controls (p. ≤. 0.003), lung weights and tissue composition remained unchanged, and lung compliance was normal. At 15 weeks post-surgery increased lung oedema was evident in AAB rats (p. =. 0.002) without decreased lung compliance or evidence of tissue remodelling. Conclusion: Despite chronically elevated Pmv, comparable to that resulting from past myocardial infarction (LVEDP. >. 19. mmHg), there is no evidence of pulmonary remodelling in the AAB model of CHF.
KW - Abdominal aortic banding
KW - Lung mechanics
KW - Pulmonary oedema
KW - Pulmonary remodelling
KW - Rat
UR - http://www.scopus.com/inward/record.url?scp=84921461613&partnerID=8YFLogxK
U2 - 10.1016/j.hlc.2014.08.009
DO - 10.1016/j.hlc.2014.08.009
M3 - Article
VL - 24
SP - 158
EP - 164
JO - Heart, Lung and Circulation
JF - Heart, Lung and Circulation
SN - 1443-9506
IS - 2
ER -