Pulmonary hypertension and right heart dysfunction in chronic lung disease

Amirmasoud Zangiabadi, Carmine De Pasquale, Dimitar Sajkov

    Research output: Contribution to journalArticle

    38 Citations (Scopus)

    Abstract

    Group 3 pulmonary hypertension (PH) is a common complication of chronic lung disease (CLD), including chronic obstructive pulmonary disease (COPD), interstitial lung disease, and sleep-disordered breathing. Development of PH is associated with poor prognosis and may progress to right heart failure, however, in the majority of the patients with CLD, PH is mild to moderate and only a small number of patients develop severe PH. The pathophysiology of PH in CLD is multifactorial and includes hypoxic pulmonary vasoconstriction, pulmonary vascular remodeling, small vessel destruction, and fibrosis. The effects of PH on the right ventricle (RV) range between early RV remodeling, hypertrophy, dilatation, and eventual failure with associated increased mortality. The golden standard for diagnosis of PH is right heart catheterization, however, evidence of PH can be appreciated on clinical examination, serology, radiological imaging, and Doppler echocardiography. Treatment of PH in CLD focuses on management of the underlying lung disorder and hypoxia. There is, however, limited evidence to suggest that PH-specific vasodilators such as phosphodiesterase-type 5 inhibitors, endothelin receptor antagonists, and prostanoids may have a role in the treatment of patients with CLD and moderate-to-severe PH.

    Original languageEnglish
    Article number739674
    Pages (from-to)Art ID 739674
    Number of pages13
    JournalBioMed Research International
    Volume2014
    Issue number2014
    DOIs
    Publication statusPublished - 2014

    Fingerprint Dive into the research topics of 'Pulmonary hypertension and right heart dysfunction in chronic lung disease'. Together they form a unique fingerprint.

  • Cite this

    Zangiabadi, A., De Pasquale, C., & Sajkov, D. (2014). Pulmonary hypertension and right heart dysfunction in chronic lung disease. BioMed Research International, 2014(2014), Art ID 739674. [739674]. https://doi.org/10.1155/2014/739674