PZP and PAI-2: Structurally-diverse, functionally similar pregnancy proteins?

Amy R. Wyatt, Jordan H. Cater, Marie Ranson

Research output: Contribution to journalArticle

10 Citations (Scopus)
2 Downloads (Pure)

Abstract

Pregnancy zone protein (PZP) and plasminogen activator inhibitor type 2 (PAI-2) are two multifunctional proteins that are elevated in normal pregnancy and numerous other inflammatory states. Both proteins were originally identified as protease inhibitors, but current evidence supports the notion that they may also function as modulators of T-helper cells and/or extracellular chaperones. Exacerbated inflammation, fibrinolytic disturbances and misfolded proteins are all implicated in the pathology of preeclampsia, a leading cause of maternal and foetal mortality and morbidity. Notably, reduced levels of PZP or PAI-2 are associated with preeclampsia and clarification of their diverse functions in normal pregnancy could provide much needed insight regarding the pathogenesis of this disorder. Given that inflammation and protein misfolding underlie the pathology of a very large number of disorders, the contributions of PZP and PAI-2 to extracellular proteostasis and immunoregulation could be broad-reaching.

Original languageEnglish
Pages (from-to)113-117
Number of pages5
JournalInternational Journal of Biochemistry and Cell Biology
Volume79
DOIs
Publication statusPublished - Oct 2016
Externally publishedYes

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