QT and QT dispersion intervals in long-standing and moderately active rheumatoid arthritis: results from a multicentre cross-sectional study

Gian Luca Erre, Alessandra Piras, Matteo Piga, Anna L. Fedele, Arduino A. Mangoni, Pietro E. Lazzerini, Elisa Gremese, Alessandro Mathieu, Gianfranco Ferraccioli, Giuseppe Passiu, Pier S. Saba, EDRA study group., Silvia Mura, Maria Cadoni, Maria Longu, Loredana Taras, Marco Piras, Ignazio Cangemi, Martina Dessi, Maria FaddaMasia Pietro

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

OBJECTIVES: To define the prevalence of prolonged QT interval and QT dispersion (QTd) in rheumatoid arthritis (RA) patients and in a control population. METHODS: QT interval corrected by Bazett's formula (QTc) was calculated from standard 12-lead ECGs in 963 subjects free of previous cardiovascular events (646 RA patients and 317 controls strictly matched for age, sex and cardiovascular risk factors). RESULTS: RA patients (59.6±9.6 years, 68.1% females) had a long mean disease duration (10.6 years) and moderate disease activity (DAS28=3.68±1.23). QTc was 5 msec longer in RA patients than in controls (412±9 vs. 407±28 msec, p=0.013). However, the prevalence of QTc prolongation in RA patients and controls was not significantly different (5.3% vs. 6.3%, p=0.50). On the contrary, RA patients had a significantly greater QTd (42±26 vs. 35±18 msec, p<0.001) and a higher prevalence of increased QTd (33.3% vs. 18.3%, p<0.001) than controls. Furthermore, RA was independently associated to increased QTd [OR(95%CI)= 2.21(1.58-3.08), p=0.0001]. In the RA population, male gender and older age were independently associated with a higher prevalence of prolonged QTd. CONCLUSIONS: In this cohort of long-standing and moderately active RA patients, RA showed longer QTc but similar prevalence of prolonged QTc and an increased QTd with a 1.8-fold higher prevalence of increased QTd than the control population. Further studies in larger prospective cohorts are warranted to investigate whether QTd prolongation predicts sudden cardiac death and other adverse cardiovascular outcomes in RA.

Original languageEnglish
Pages (from-to)516-522
Number of pages7
JournalClinical and Experimental Rheumatology
Volume38
Issue number3
Publication statusPublished - May 2020

Keywords

  • rheumatoid arthritis
  • QT dispersion
  • QT prolongation
  • arrhythmias
  • electrocardiography

Fingerprint Dive into the research topics of 'QT and QT dispersion intervals in long-standing and moderately active rheumatoid arthritis: results from a multicentre cross-sectional study'. Together they form a unique fingerprint.

  • Cite this

    Erre, G. L., Piras, A., Piga, M., Fedele, A. L., Mangoni, A. A., Lazzerini, P. E., Gremese, E., Mathieu, A., Ferraccioli, G., Passiu, G., Saba, P. S., EDRA study group., Mura, S., Cadoni, M., Longu, M., Taras, L., Piras, M., Cangemi, I., Dessi, M., ... Pietro, M. (2020). QT and QT dispersion intervals in long-standing and moderately active rheumatoid arthritis: results from a multicentre cross-sectional study. Clinical and Experimental Rheumatology, 38(3), 516-522. https://www.clinexprheumatol.org/abstract.asp?a=14310