Qualitative phenotyping of obstructive sleep apnea and its clinical usefulness for the sleep specialist

Marcello Bosi, Andrea De Vito, Danny Eckert, Joerg Steier, Bhik Kotecha, Claudio Vicini, Venerino Poletti

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    20 Citations (Scopus)
    25 Downloads (Pure)


    Introduction: The anatomical collapsibility of the upper airway, neuromuscular tone and function, sleep–wake and ventilatory control instability, and the arousal threshold all interact and contribute to certain pathophysiologic features that characterize different types of obstructive sleep apnea (OSA). A model of qualitative phenotypizationallowsus to characterize the different pathophysiological traits in OSA patients.Methods: A narrative review was performed, to analyze the available literature evidence, with the purpose of generating a model of qualitative phenotypization to characterize pathophysiological traits in patients with OSA.Results: 96 out of 3829 abstracts were selected for full-text review. Qualitative phenotyping model of OSA:Data concerning the OSA qualitative pathophysiological traits’ measurement can be deducted by means of clinical PSG, grade of OSA severity, and therapeutic level of Continuous Positive Airway Pressure (CPAP) and are reported in the text. This approach would allow qualitative phenotyping with widely accessible methodology in a routine clinical scenario and is of particular interest for the sleep specialist, surgical treatment decision-making, and customized OSA multimodality treatment.

    Original languageEnglish
    Article number2058
    Number of pages15
    JournalInternational Journal of Environmental Research and Public Health
    Issue number6
    Publication statusPublished - Mar 2020

    Bibliographical note

    This article is an open access
    article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).


    • CPAP
    • Obstructive sleep apnea
    • Pathophysiological traits
    • Phenotypization


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