Qualitative phenotyping of obstructive sleep apnea and its clinical usefulness for the sleep specialist

Marcello Bosi; Andrea De Vito; Danny Eckert; Joerg Steier; Bhik Kotecha; Claudio Vicini; Venerino Poletti

doi:10.3390/ijerph17062058

Qualitative phenotyping of obstructive sleep apnea and its clinical usefulness for the sleep specialist

Marcello Bosi, Andrea De Vito, Danny Eckert, Joerg Steier, Bhik Kotecha, Claudio Vicini, Venerino Poletti

Research output: Contribution to journal › Review article › peer-review

23 Citations (Scopus)

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Abstract

Introduction: The anatomical collapsibility of the upper airway, neuromuscular tone and function, sleep–wake and ventilatory control instability, and the arousal threshold all interact and contribute to certain pathophysiologic features that characterize different types of obstructive sleep apnea (OSA). A model of qualitative phenotypizationallowsus to characterize the different pathophysiological traits in OSA patients.Methods: A narrative review was performed, to analyze the available literature evidence, with the purpose of generating a model of qualitative phenotypization to characterize pathophysiological traits in patients with OSA.Results: 96 out of 3829 abstracts were selected for full-text review. Qualitative phenotyping model of OSA:Data concerning the OSA qualitative pathophysiological traits’ measurement can be deducted by means of clinical PSG, grade of OSA severity, and therapeutic level of Continuous Positive Airway Pressure (CPAP) and are reported in the text. This approach would allow qualitative phenotyping with widely accessible methodology in a routine clinical scenario and is of particular interest for the sleep specialist, surgical treatment decision-making, and customized OSA multimodality treatment.

Original language	English
Article number	2058
Number of pages	15
Journal	International Journal of Environmental Research and Public Health
Volume	17
Issue number	6
DOIs	https://doi.org/10.3390/ijerph17062058
Publication status	Published - Mar 2020

Bibliographical note

This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

Keywords

CPAP
Obstructive sleep apnea
Pathophysiological traits
Phenotypization

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ijerph17062058Licence: CC BY

Published versionFinal published version, 2.21 MBLicence: CC BY

Cite this

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AU - Bosi, Marcello

AU - De Vito, Andrea

AU - Eckert, Danny

AU - Steier, Joerg

AU - Kotecha, Bhik

AU - Vicini, Claudio

AU - Poletti, Venerino

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N2 - Introduction: The anatomical collapsibility of the upper airway, neuromuscular tone and function, sleep–wake and ventilatory control instability, and the arousal threshold all interact and contribute to certain pathophysiologic features that characterize different types of obstructive sleep apnea (OSA). A model of qualitative phenotypizationallowsus to characterize the different pathophysiological traits in OSA patients.Methods: A narrative review was performed, to analyze the available literature evidence, with the purpose of generating a model of qualitative phenotypization to characterize pathophysiological traits in patients with OSA.Results: 96 out of 3829 abstracts were selected for full-text review. Qualitative phenotyping model of OSA:Data concerning the OSA qualitative pathophysiological traits’ measurement can be deducted by means of clinical PSG, grade of OSA severity, and therapeutic level of Continuous Positive Airway Pressure (CPAP) and are reported in the text. This approach would allow qualitative phenotyping with widely accessible methodology in a routine clinical scenario and is of particular interest for the sleep specialist, surgical treatment decision-making, and customized OSA multimodality treatment.

AB - Introduction: The anatomical collapsibility of the upper airway, neuromuscular tone and function, sleep–wake and ventilatory control instability, and the arousal threshold all interact and contribute to certain pathophysiologic features that characterize different types of obstructive sleep apnea (OSA). A model of qualitative phenotypizationallowsus to characterize the different pathophysiological traits in OSA patients.Methods: A narrative review was performed, to analyze the available literature evidence, with the purpose of generating a model of qualitative phenotypization to characterize pathophysiological traits in patients with OSA.Results: 96 out of 3829 abstracts were selected for full-text review. Qualitative phenotyping model of OSA:Data concerning the OSA qualitative pathophysiological traits’ measurement can be deducted by means of clinical PSG, grade of OSA severity, and therapeutic level of Continuous Positive Airway Pressure (CPAP) and are reported in the text. This approach would allow qualitative phenotyping with widely accessible methodology in a routine clinical scenario and is of particular interest for the sleep specialist, surgical treatment decision-making, and customized OSA multimodality treatment.

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Qualitative phenotyping of obstructive sleep apnea and its clinical usefulness for the sleep specialist

Abstract

Bibliographical note

Keywords

UN SDGs

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